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| Increased folds of EC50 | ||||
| >20 | 4–20 | <4 | ||
| V106M | A98G* | (V108I)* | ||
| Y181C* | (V108I)/T386A | I135T | ||
| I135T/I382L* | (I178M) | |||
| K238N/T48I/(I178M) | V189I | |||
| V314A | ||||
| I382L | ||||
| T386A | ||||
| (I178M)/I382V | ||||
Novel mutations were bold. Initial mutations were labeled with *. Mutations in parentheses appeared in different mutation profiles.
