Skip to main content
. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Metabolism. 2012 May 17;62(1):12–20. doi: 10.1016/j.metabol.2012.04.009

Table 2.

Evidence for Clinical Applications of microRNA in in vitro Studies of Human-Derived Cell Lines and in vivo Studies of Humans and Related Primates

miR species Markers of response Targeted interventions
33 miR-33 is down regulated by cholesterol enrichment in human THP-1 macrophages in vitro (Rayner et. al., 2010) miR-33 inhibition decreased serum triglycerides and increased HDL-c in African Green Monkeys and upregulated fatty acid oxidation and hepatic insulin response in Huh2 hepatocytes in vitro (Rayner et. al., 2011); miR- 33 inhibition decreased expression of Insulin Receptor Substrate 2 mRNA in HepG2 hepatocytes in vitro (Davalos, et. al., 2011)
122 miR-122 inhibition decreased expression of Sterol Regulatory Element Binding Factor 1c mRNA (Iliopoulos, et. al., 2010) and increased bile acid concentrations in HepG2 hepatocytes in vitro (Song et. al., 2010)
370 miR-370 transfection upregulated Sterol Regulatory Binding Factor 1c, Diacylglycerol O-Acyltransferase 2, Fatty Acid Synthase, and acyl-CoA carboxylase 1 in HepG2 hepatocytes in vitro (Iliopoulos et. al., 2010)
758 Inhibition of miR-758 decreased Adenosine Triphosphate Binding Cassette Transporter mRNA in THP-1 macrophages in vitro (Ramirez et. al., 2011)
21 miR-21 is upregulated by elevated free fatty acids secondary to obesity in human liver (Vinciguerra et. al., 2009)
125-5p miR125-5p is upregulated in THP-1 monocytes exposed to oxidized LDL-c in vitro (Chen et. al., 2009) Inhibition of mir-125-5p increased total cholesterol and oxidized LDL-c uptake, and altered expression of inflammatory markers in THP-1 monocytes in vitro (Chen et. al., 2009)

microRNA (miR)

High-density lipoprotein cholesterol (HDL-c)

Messenger RNA (mRNA)

Low-density lipoprotein cholesterol (LDL-c)