Table 1.

The acute cerebral metabolic response to citalopram in men and women.

Regions of Decrease in Women
Right Hemisphere				Brain Region	Left Hemisphere
Talairach Coordinates					Talairach Coordinates
x (mm)	y (mm)	z (mm)	Z score		x (mm)	y (mm)	z (mm)	Z score
				Midbrain (substantia nigra)	−5	−13	−11	3.14
29	−71	19	3.58*	Middle Temporal Gyrus
37	−86	17	3.42*	Middle Occipital Gyrus

Regions of Increase in Women
Right Hemisphere				Brain Region	Left Hemisphere
Talairach Coordinates					Talairach Coordinates
x (mm)	y (mm)	z (mm)	Z score		x (mm)	y (mm)	z (mm)	Z score
				Superior Frontal Gyrus	−18	55	15	3.67**
				Anterior Cingulate Gyrus (BA 24)	−4	13	29	2.71
5	;67	18	2.71	Posterior Cingulate (BA 31)	−2	−65	14	2.98*
				Uncus (BA 28)	−23	−12	−27	3.01
				Superior Temporal Gyrus	−58	−39	20	3.57**
44	−21	12	3.12	Transverse Temporal Gyrus
44	−59	36	2.98	Angular Gyrus
48	−56	45	2.89	Inferior Parietal Lobule (BA 40)
48	−23	52	3.36	Postcentral Gyrus
11	−44	49	3.78**	Precuneus (BA 7)
				Putamen	−21	6	−4	3.44*
3	−17	4	3.62*	Thalamus	−19	−34	5	4.75*

Regions of Decrease in Men
Right Hemisphere				Brain Region	Left Hemisphere
Talairach Coordinates					Talairach Coordinates
x (mm)	y (mm)	z (mm)	Z score		x (mm)	y (mm)	z (mm)	Z score
0	−18	31	2.75**	Anterior Cingulate Gyrus (BA 23)	−6	−31	34	4.05*
19	40	−16	4.07**	Superior Frontal Gyrus	−8	10	52	3.18
38	28	30	3.66**	Middle Frontal Gyrus	−30	38	41	3.68
42	8	6	3.88**	Precentral Gyrus (BA 44)	−36	2	27	3.40
48	−55	16	3.76*	Superior Temporal Gyrus (BA 22)
				Superior Parietal Lobule (BA 7)	−26	−58	62	3.65
1	−39	22	3.12*	Posterior Cingulate
20	−61	52	3.21	Precuneus
61	−38	30	3.61*	Inferior Parietal Lobule
Regions of Increase in Men: None