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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Trends Immunol. 2012 Jun 5;33(10):488–495. doi: 10.1016/j.it.2012.04.007

Figure 1. Immediate-early uptake of Lm from the blood.

Figure 1

Marginal zone phagocytes, including neutrophils, monocytes, macrophages (MΦ), and dendritic cells (DC) engulf blood-borne Lm. Ly6G+ neutrophils and Ly6G- macrophages kill phagocytosed Lm to control bacterial growth. Deposition of complement component C3b on Lm promotes bacterial binding to and aggregation of CD41+ platelets. These aggregates are phagocytosed by CD8α+CD11c+ DCs, shielding Lm from other more microbicidal phagocytes. Migration of DCs to the PALS permits increased bacterial replication during systemic infection.