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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Trends Immunol. 2012 Jun 5;33(10):488–495. doi: 10.1016/j.it.2012.04.007

Figure 2. Consequences of Lm infection in the splenic PALS.

Figure 2

By 24 h post-infection (hpi), both uninfected and Lm-associated CD8α+CD11c+ dendritic cells migrate from the marginal zone into the PALS. Rapid bacterial expansion ensues in one or more cell types. Dendritic cells mature in response to inflammatory cytokines, allowing them to activate natural killer cells and prime naïve CD4+ and CD8+ T cells.