Figure 4. Effects of high-dose cocaine self-administration and abstinence on delayed match-to-sample performance.

Group data (mean ± SEM) for monkeys with a cocaine self-administration history (top) and cocaine-naive control monkeys (bottom). Data are expressed in 5-day bins as a percent of baseline performance for each delay (short, mid, long) when 0.1 mg/kg/injection cocaine was self-administered each previous afternoon (cocaine-experienced) or the equivalent 5-day period when food pellets were self-administered (cocaine-naive); * denotes significant difference from 5 day baseline average (p<0.05).