Table 3.
Individual delays generating high, middle, and low percent accuracies and cocaine intake (mg/kg/session) and response rates (resp/sec).
| Exp. 3 | Cocaine self-administration | |||||
|---|---|---|---|---|---|---|
| Starting delays (sec) | BL (0.1 mg/kg/inj) | Increased Access (0.3 mg/kg/inj) | ||||
| Day 1-5 | Day 1-5 | Day 6-10 | ||||
| short | mid | long | Intake/rate¶ | Intake/rate | Intake/rate | |
| Coc-Exp (Monkey) | ||||||
| R-1374 | 0 | 60 | 120 | 1.5/0.18 | 4.38/0.08 | 4.14/0.06 |
| R-1375 | 0 | 45 | 90 | 1.5/0.16 | 3.06/0.04 | 3.12/0.04 |
| R-1377 | 0 | 45 | 90 | 1.5/0.29 | 3.30/0.05^ | 3.00/0.12^ |
| AVE | 1.5/0.21 | 3.58/0.06 | 3.42/0.07 | |||
| Coc-naive (Monkey) | Pellets (total #) | |||||
| R-1681 | 5 | 60 | 120 | 15/2.14 | -- | -- |
| R-1682 | 0 | 60 | 120 | 15/1.56 | -- | -- |
| R-1696 | 0 | 45 | 90 | 15/2.48 | -- | -- |
| R-1756 | 5 | 30 | 60 | 15/0.35 | -- | -- |
^
Dose was decreased from 0.3 to 0.2 mg/kg on day 5; averages are for days 1-4 and 5-10
¶
first number represents reinforcement frequency (mg/kg/session for coc-exp monkeys and # pellets for coc-naïve animals) and second number represent response rates (responses/second)