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. Author manuscript; available in PMC: 2013 Nov 15.
Published in final edited form as: Biol Psychiatry. 2012 Jun 8;72(10):803–810. doi: 10.1016/j.biopsych.2012.04.026

Figure 4. Adolescent THC regulates Penk gene expression and histone H3 methylation in NAcsh.

Figure 4

(A) NAcsh Penk mRNA levels 1 day (adolescent) and 30 days (adult) after adolescent THC or vehicle (n=9–10/group). (B)–(E) NAcsh histone H3 methylation fold changes at the Penk gene 1 day and 30 days after the last adolescent exposure to THC relative to vehicle treated animals (n=6–8/group (3 animals pooled/n)). (B) H3K9me2. (C) H3K9me3. (D) H3K36me3. (E) H3K4me3. Data shown as mean±SEM.*P<0.05; **P<0.01; ***P<0.001 compared to vehicle-exposed animals at the same time point. kb, kilobases; TSS, transcription start site. See also Fig. S3 and Table S2 in the Supplement.