Fig. 6.

a CT imaging of case 13 before the introduction of anti-TNFα therapy. Bronchiectasis is prominent. b After 15 months of anti-TNFα therapy (infliximab for 9 months and etanercept for 6 months), centrilobular small nodules, tree-in-bud sign, bronchiectasis/bronchiolectasis, and ground-glass opacities have developed in both lungs. c A CT scan taken after 10 months of anti-NTM therapy. d Abnormal findings indicative of the nodular/bronchiectatic form have appeared after tocilizumab was introduced for 3 months. e A CT scan taken after 7 months of anti-NTM therapy. Architectural distortion was not evident at any point in the clinical course