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Effect of exercise and high-fat diet in C57BL/6J mice on (A) body weight. +P<0.05 and ++P<0.01, difference EF vs. EN. **P<0.01 compared to other groups, (B) wheel running distance, (C) food intake. *P<0.05 and **P<0.01, (D) body temperature. *P<0.05, difference EF vs. SN. SN, normal diet in non-exercise groups; EN, normal diet in exercise groups; SF, high-fat diet in non-exercise groups; EF, high-fat diet in exercise groups.
