Table II.
Comparison of the expression of the ten biomarkers between melanomas with and without metastasis.
| Biomarker | IRS mean value
|
P-valuea | |
|---|---|---|---|
| AJCC I–II (n=70) | AJCC III–IV (n=48) | ||
| Bim | 5.30 | 2.83 | 0.0001 |
| BRMS1 | 5.99 | 4.45 | 0.0030 |
| BRG1 | 6.09 | 6.08 | 0.9253 |
| CTHRC1 | 6.00 | 6.75 | 0.1342 |
| ING4 | 5.86 | 4.75 | 0.0239 |
| NQO1 | 4.96 | 2.75 | 0.0008 |
| NF-κB-p50 | 4.84 | 5.71 | 0.1424 |
| PUMA | 4.89 | 4.19 | 0.0379 |
| SNF5 | 5.84 | 5.87 | 0.9430 |
| SOX4 | 5.77 | 4.35 | 0.0115 |
| 6-Biomarker system | 26.99b | 18.98b | <0.0001 |
a
Calculated using the Mann-Whitney test.
b
Mean value of the combined six biomarkers, including Bim, BRMS1, ING4, NQO1, PUMA and SOX4.