Table IX.
Genes (14) that were up- or down-regulated following administration of hydralazine, and/or were commonly more highly expressed in the kidneys of the SHRs, SHRSPs or M-SHRSPs compared to the WKY rats at 9 compared to 6 weeks of age.
| A, Genes strongly suggested to be associated with hypertension | |||||
|
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| Fold changes (hydralazine/none) | Strains | Clones | GB account | Description | |
|
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| 1.a | 9.646 | 6W M-SHRSP | A_44_P566390 | TC550463 | Farnesyl pyrophosphate synthetase |
| 2.a | 9.551 | 6W M-SHRSP | A_44_P623610 | TC525804 | Unknown |
| 3.a | 8.615 | 6W M-SHRSP | A_43_P10474 | TC527985 | Unknown |
| 4.a | 8.419 | 6W M-SHRSP | A_44_P808679 | TC541828 | Unknown |
| 5.a | 8.387 | 6W M-SHRSP | A_44_P104687 | Kcnc3 | Potassium voltage-gate channel protein |
| 6.a | 2.044 | 6W SHRSP | A_44_P871211 | TC566645 | Unknown |
| 7.a | 0.664 | 9W SHR | A_44_P732488 | TC567669 | Unknown |
| 8. | 2.367 | 6W SHR | |||
| 2.529 | 6W SHRSP | A_42_P811256 | Vnn1 | Participate in an oxidative-stress response | |
| 9. | 2.205 | 6W SHRSP | |||
| 8.872 | 6W M-SHRSP | A_44_P854454 | TC543180 | Unknown | |
| 10. | 1.260 | 9W SHR | |||
| 2.115 | 6W SHRSP | A_44_P435955 | RGD1561143_predicted | Similar to cell surface receptor FDFACT | |
|
| |||||
| B, Genes possibly suggested to be associated with hypertension | |||||
|
| |||||
| 1.b | 9.245 | 6M M-SHRSP | A_44_P610417 | TC560558 | FK506-binding protein 1B |
| 2.c | 8.997 | 6W M-SHRSP | A_44_P841829 | TC564079 | CG4187-PA, Drosophila melanogaster |
| 3.b | 8.969 | 6W M-SHRSP | A_44_P917243 | TC533180 | Unknown |
| 4.b | 8.533 | 6W M-SHRSP | A_44_P408114 | XM_343516 | Similar to sulfotransferase K2 |
a
More highly expressed at 9 than at 6 weeks of age in either SHR or SHRSP;
b
More highly expressed at 9 than at 6 weeks of age in SHRSP;
c
More highly expressed at 9 than at 6 weeks of age in SHR.