Table IV.

Contribution of the intensity scores and frequency scores to the overall immunoreactivity scores for expression of the integrins and ligands in the tumors and squamous epithelium of the controls both in the endothelium and stroma, respectively.^a

		Squamous cell carcinoma	Squamous epithelium controls	Endothelium		Stroma
				Tumors	Controls	Tumors	Controls
Integrin αvβ3	Intensity	0.21±0.57	0.30±0.60	3.60±0.77	3.30±0.80	0.80±0.67	0.20±0.30
	Frequency	0.72±1.41	0.60±1.10	3.59±0.84	2.70±1.40	3.18±1.48	1.90±2.00
	Immunoreactivity score	0.29±0.62	0.40±0.60	13.18±4.37	9.00±5.60	3.06±2.60	0.70±0.80
Integrin αvβ5	Intensity	2.00±0.90	1.50±0.90	2.70±1.10	2.40±1.00	2.60±1.40	1.30±1.00
	Frequency	3.20±0.90	2.60±1.10	2.60±1.10	2.60±1.30	3.80±0.70	3.50±1.40
	Immunoreactivity score	6.10±3.40	3.40±2.10	7.30±4.90	6.60±5.00	10.2±5.40	4.90±4.00
Integrin α5β1	Intensity	1.70±0.90	1.30±0.70	2.10±0.90	1.60±0.90	1.80±0.80	0.80±0.40
	Frequency	3.00±1.00	2.90±0.90	2.10±1.20	2.20±1.30	3.80±0.50	3.60±1.10
	Immunoreactivity score	5.00±2.70	3.60±1.90	4.40±3.00	3.40±2.80	6.70±2.90	3.00±1.70
Fibrinogen	Intensity	1.30±0.90	2.30±1.40	4.00±0.20	3.60±0.60	4.00±0.00	3.80±0.60
	Frequency	3.20±1.10	2.40±0.90	3.60±0.80	2.90±1.20	3.90±0.60	4.00±0.00
	Immunoreactivity score	4.10±3.10	5.20±3.20	14.40±3.30	10.1±4.70	15.7±2.20	15.2±2.20
Osteopontin	Intensity	2.30±0.80	2.90±1.30	1.80±1.20	1.60±1.50	0.80±0.70	0.30±0.40
	Frequency	3.20±0.90	3.00±0.80	1.40±0.80	1.50±1.10	3.90±0.50	2.60±2.00
	Immunoreactivity score	7.40±3.60	8.00±4.20	2.60±2.10	2.30±2.00	3.00±2.80	1.10±1.50
Vitronectin	Intensity	2.30±1.10	2.30±1.30	2.80±1.40	2.80±1.30	1.30±0.90	1.10±0.90
	Frequency	3.40±0.80	3.00±1.10	2.60±1.20	2.50±1.30	3.80±0.60	3.90±0.60
	Immunoreactivity score	7.50±3.60	7.10±4.80	7.60±5.40	7.30±6.00	4.90±2.20	4.50±3.80
Fibronectin	Intensity	0.60±0.60	1.20±1.30	3.80±0.60	3.30±0.80	3.90±0.30	3.40±0.90
	Frequency	1.90±1.60	1.60±1.50	3.70±0.70	2.90±1.10	4.00±0.30	4.00±0.00
	Immunoreactivity score	1.60±2.20	2.90±4.00	14.30±3.70	9.50±4.80	15.5±1.60	13.8±3.80
CD31	Intensity	0.01±0.00	0.01±0.05	4.00±0.00	3.90±0.50	0.70±0.70	0.90±1.40
	Frequency	0.10±0.40	0.20±0.90	4.00±0.00	4.00±0.20	3.10±1.50	2.10±1.90
	Immunoreactivity score	0.02±0.09	0.04±0.20	16.0±0.00	15.5±2.20	2.40±2.10	2.10±2.20

^aAlso see to Fig. 1. Values are represented as the means ± SD. Data are from 40 tumor samples (Table I) and 20 control samples (Table II). Control tissues for tumors were samples of non-cancerous squamous epithelium.