Table I.

Antitumor effect of TAS-102 and capecitabine in human colorectal cancer CO-3 cells.

Drug	Dose (mg/kg/day)	RTVa	IRb (%)	BWCc (%)
Control	-	22.09±1.80	-	−7.86
TAS-102	75	12.27±0.86d	44.5	−10.35
TAS-102	150	10.26±0.73d	53.5	−13.17
Capecitabine	360	13.62±0.97e	38.4	−11.06

^aRelative tumor volume on day 15.

^bTumor growth inhibition rate {IR, % = [1− (average RTV in the treatment group/average RTV in the control group)] × 100}.

^cPercent weight change from pre-treatment on day 15.

^dP<0.01 vs. the control group (Dunnett's t-test).

^eP<0.01 vs. the control group (Student's t-test).