Table IV.
Univariate and multivariate Cox regression analysis of overall survival in patients with adjuvant chemotherapy.
| Factor | Cut-off point | No. of patients | Median time (months) | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Hazard ratio (95% CI) | P-value log-rank | P-value Wilcoxon | Hazard ratio (95% CI) | P-value | ||||
| Gender | ||||||||
| Male | 39 | 24.1 | 1.00 | 0.667 | 0.865 | - | ||
| Female | 18 | 25.1 | 1.19 (0.51–2.63) | |||||
| Age (years) | ||||||||
| <65 | 25 | 30.6 | 1.00 | 0.052 | 0.045a | - | ||
| ≥65 | 32 | 24.1 | 2.16 (0.99–4.96) | |||||
| UICC pTNM | ||||||||
| pT | 1/2 | 2 | Not reached | - | 0.653 | 0.656 | - | |
| 3/4 | 55 | 25.1 | - | |||||
| pN | − | 15 | 30.6 | 1.00 | 0.137 | 0.066 | - | |
| + | 42 | 23.3 | 2.22 (0.84–7.65) | |||||
| pM | − | 55 | 25.1 | 1.00 | 0.169 | 0.447 | - | |
| + | 2 | 18.4 | 2.70 (0.43–9.52) | |||||
| I–II | 55 | 25.1 | - | 0.169 | 0.447 | - | ||
| III–IV | 2 | 18.4 | - | |||||
| Histology | ||||||||
| Poor | 4 | 23.8 | 1.00 | 0.689 | 0.853 | - | ||
| Moderate | 44 | 24.1 | 0.78 (0.23–4.87) | 0.798 | 0.528 | |||
| Well | 3 | 25.4 | 0.68 (0.03–7.20) | 0.910 | 0.531 | |||
| Other | 6 | Not reached | 0.41 (0.02–4.29) | 0.512 | 0.807 | |||
| Genea | ||||||||
| ENT1 | <4.64 | 28 | 25.1 | 1.00 | 0.148 | 0.322 | - | |
| ≥4.64 | 27 | 25.1 | 1.79 (0.80–4.04) | |||||
| RRM1 | − | 35 | 25.4 | 1.00 | 0.264 | 0.211 | - | |
| + | 22 | 23.3 | 1.62 (0.65–3.70) | |||||
| RRM2 | <1.34 | 27 | 25.1 | 1.00 | 0.586 | 0.823 | - | |
| ≥1.34 | 26 | 23.3 | 1.24 (0.58–2.70) | |||||
| TS | <1.34 | 26 | 30.6 | 1.00 | 0.431 | 0.831 | - | |
| ≥1.34 | 26 | 24.1 | 1.37 (0.63–3.04) | |||||
| DPD | <0.53 | 28 | 27.2 | 1.00 | 0.166 | 0.333 | 5.55 (1.27–24.05) | 0.022a |
| ≥0.53 | 28 | 23.3 | 1.77 (0.77–4.04) | |||||
| DHFR | <1.14 | 18 | 27.3 | 1.00 | 0.203 | 0.271 | - | |
| ≥1.14 | 18 | 21.8 | 1.83 (0.70–4.80) | |||||
| FPGS | <1.21 | 26 | 16.9 | 1.00 | 0.129 | 0.023a | - | |
| ≥1.21 | 26 | 25.4 | 0.50 (0.19–1.20) | |||||
| GGH | − | 35 | 25.4 | 1.00 | 0.085 | 0.033a | 3.77 (1.04–13.79) | 0.043a |
| + | 15 | 15.4 | 2.23 (0.83–5.54) | |||||
| EGFR | <1.52 | 25 | 23.3 | 1.00 | 0.665 | 0.497 | - | |
| ≥1.52 | 26 | 24.1 | 0.84 (0.36–1.87) | |||||
| VEGF | <6.35 | 28 | 27.2 | 1.00 | 0.226 | 0.424 | - | |
| ≥6.35 | 28 | 23.3 | 1.63 (0.72–3.66) | |||||
a.
With respect to nine genes other than RRM1, part of the data was excluded from the analysis because of high DNA contamination or high coefficient of variance.