Table 2.

Islet cell ratios, islet cell, and acinar cell proliferation in 3-month-old male and female rats.

	Control	HFG	HFP	HFGP
Beta-cell to alpha-cell ratio
Males	2.71 ± 0.42 n = 3	2.70 ± 0.78 n = 3	3.08 ± 0.20 n = 4	5.07 ± 1.95 n = 3
Females	3.94 ± 0.64 n = 5	4.60 ± 0.54 n = 3	3.36 ± 0.51 n = 3	—
Alpha-cell to beta-cell ratio
Males	0.39 ± 0.07 n = 3	0.48 ± 0.19 n = 3	0.33 ± 0.02 n = 4	0.26 ± 0.08 n = 3
Females	0.28 ± 0.04 n = 5	0.22 ± 0.02 n = 3	0.31 ± 0.04 n = 3	—
Islet cell proliferation
Males	0.0023 ± 0.0003 n = 3	0.0065 ± 0.0005 n = 3	0.0125 ± 0.0039 n = 4	0.0087 ± 0.0005 n = 3
Acinar cell proliferation
Males	0.0008 ± 0.00012 n = 3	0.0017 ± 0.0004 n = 3	0.1393 ± 0.0387∗†§ n = 4	0.0062 ± 0.0014 n = 3

HFG: high-fat diet during fetal life; HFP: high-fat diet during postnatal life; HFGP: high-fat diet during both fetal and postnatal life.  Data are means ± SEM.  *P < 0.05 versus control; ^† P < 0.05 versus HFG; ^§ P < 0.05 versus HFGP.