Table 1.
Autoantibodies detected in sera of patients with HCV-related MC.
| Autoantibodies | Frequency (%) | Clinical significance | References |
|---|---|---|---|
| ANA | 12–65% | Low titer | [8, 30, 37, 49–52] |
| Speckled pattern on HEp-2 cells | |||
| SMA | 33–37% | Low titer | [8, 53] |
| RF | 14–99% | Low titer | [30, 37, 49, 52, 54, 55] |
| ANCA (pANCA, cANCA) | 4–26% | No association with vasculitis | [57, 58] |
| Anti-CRP | 75% | Predictive marker of cryoglobulinemia | [59, 60] |
| Anti-C1q | 39% | Predictive marker of type III cryoglobulinemia | [61] |
| AECA | 50% | Predictive marker of vasculitis | [62] |
| Anti-GM1 ganglioside antisulfatide | 52% | Predictive marker of peripheral neuropathy | [63] |