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. 2012 Jul 12;55(17):7346–7359. doi: 10.1021/jm300346w

Figure 7.

Figure 7

Bromodomain classification tree generated on the basis of eight binding site amino acid signatures showing bromodomain druggability. Numbering and branch colors consistent with groupings from Table 2. Druggability classification colors consistent with Figure 4 and Figure 5. Druggabilities of ASH1L, ATAD2B, BRPF1B, PB1(A/B/C)(3), PB1(A/B/C)(4), and SMARCA2B assessed using structures failing imposed filters included (see group text).