Table 2.
Metabolic parameters from mice fed with control diet (CD) or high-fat diet (HFD), supplemented, or not with sunflower oil (rich in n-6 fatty acids).
| CD | HFD | CD + n6 | HFD + n6 | |
|---|---|---|---|---|
| Fasted glucose (mg/dL) | 186.1 ± 5.66 | 221.0 ± 8.38* | 173.8 ± 4.75 | 196.8 ± 10.66 |
| GTT test (AUC) | 7987 ± 779.3 | 13090 ± 643.9* | 7568 ± 1359 | 14790 ± 1731# |
| ITT test (% glucose/min) | 2.97 ± 0.19 | 2.13 ± 0.21* | 1.94 ± 0.30* | 1.98 ± 0.22 |
| Total cholesterol (mg/dL) | 148.2 ± 6.72 | 192.7 ± 11.96* | 164.3 ± 14.00 | 166.3 ± 12.33 |
| LDL cholesterol (mg/dL) | 127.4 ± 5.15 | 165.1 ± 14.49* | 128.2 ± 13.77 | 136.7 ± 13.22 |
| HDL cholesterol (mg/dL) | 14.73 ± 0.83 | 15.52 ± 1.86 | 19.33 ± 2.21 | 15.00 ± 1.15 |
| Triglycerides (mg/dL) | 68.61 ± 5.56 | 63.00 ± 4.40 | 84.70 ± 8.53 | 72.78 ± 8.71 |
Oral supplementation with n-6 (2 g/Kg body weight, three times a week, gavage) or water have started four weeks before HFD and continued until the end of experimental period. Animals were fed HFD or CD for eight weeks. GTT: glucose tolerance test; ITT: insulin tolerance test. Mean ± SEM (n = 6–15). ANOVA two-way with Bonferroni post tests. *P < 0.05 when compared with CD; #P < 0.05 when compared with CD + n6.