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. Author manuscript; available in PMC: 2013 Sep 6.
Published in final edited form as: Neuron. 2012 Sep 6;75(5):916–927. doi: 10.1016/j.neuron.2012.06.035

Figure 5. Odor evidence integration in medial OFC.

Figure 5

(A) Idealized time-series profiles of evidence integration for 3-, 4-, and 5-sample (sniff) trials were generated from behaviorally-derived parameters from each subject’s collapsing-bounds DDM. (B) Regression of the fMRI time-series data against the integration profiles in (A) revealed significant activation in medial OFC (p < 0.05, small-volume corrected). Images overlaid on coronal (top) and axial (bottom) sections of the mean T1-weighted MRI scan (display threshold, p < 0.005; error bars, SEM.). (C–D) Group-averaged deconvolved fMRI time-series (pooled across all significant voxels, p < 0.005) from right (C) and left (D) OFC demonstrate that orbitofrontal activity increases over time and peaks at the time of decision. All activations are normalized to odor onset. *, p < 0.05; †, p < 0.01, differences from baseline.