FIGURE 5.

Principal components analysis scores determined from mouse urine samples analyzed by UPLC-ESI-QTOFMS 7 d (A; ESI⁻: R² = 0.631, Q² = 0.040) and 14 d (B; ESI⁻: R² = 0.635, Q² = 0.041) after dosing. C: PLS-DA scores from mouse urine samples analyzed by UPLC-ESI-QTOFMS before dosing and 7 and 14 d after dosing. ■, before dosing; △, α-tocopherol–deficient (basal) diet 7 d after dosing; ▴, α-tocopherol–enriched diet 7 d after dosing; ○, α-tocopherol–deficient (basal) diet 14 d after dosing; •, α-tocopherol–enriched diet 14 d after dosing (ESI⁻: R²X = 0.260, R²Y = 0.590, Q² = 0.274). PLS-DA, projection to latent structures discriminant analysis; UPLC-ESI-QTOFMS, ultraperformance liquid chromatography–electrospray ionization–quadrupole time-of-flight mass spectrometry.