TABLE 2.
RRs of colorectal cancer by total vitamin B-6 intake in the Nurses’ Health Study (1980–2008)1
| Quintiles of intake |
||||||
| 1 | 2 | 3 | 4 | 5 | P-trend | |
| Baseline | ||||||
| No. of cases (n = 1614) | 324 | 329 | 400 | 260 | 301 | |
| Model 1 | 1.0 (reference)2 | 0.85 (0.73, 0.99) | 0.91 (0.78, 1.05) | 0.73 (0.62, 0.86) | 0.73 (0.63, 0.86) | <0.001 |
| Model 2 | 1.0 (reference) | 0.87 (0.74, 1.01) | 0.94 (0.81, 1.09) | 0.78 (0.66, 0.91) | 0.79 (0.67, 0.93) | 0.01 |
| Model 3 | 1.0 (reference) | 0.86 (0.73, 1.02) | 0.95 (0.80, 1.14) | 0.83 (0.65, 1.04) | 0.84 (0.66, 1.07) | 0.45 |
| Cumulative average | ||||||
| No. of cases (n = 1614) | 320 | 360 | 328 | 303 | 303 | |
| Model 1 | 1.0 (reference) | 0.96 (0.83, 1.12) | 0.84 (0.72, 0.98) | 0.77 (0.66, 0.91) | 0.78 (0.66, 0.91) | 0.003 |
| Model 2 | 1.0 (reference) | 1.03 (0.89, 1.20) | 0.96 (0.82, 1.12) | 0.90 (0.77, 1.06) | 0.92 (0.79, 1.08) | 0.22 |
| Model 3 | 1.0 (reference) | 0.98 (0.82, 1.17) | 0.91 (0.74, 1.12) | 0.95 (0.76, 1.19) | 1.00 (0.80, 1.24) | 0.55 |
| Simple update (0–4-y lag) | ||||||
| No. of cases (n = 1375) | 319 | 283 | 281 | 247 | 245 | |
| Model 1 | 1.0 (reference) | 0.87 (0.74, 1.02) | 0.81 (0.69, 0.95) | 0.71 (0.60, 0.84) | 0.70 (0.59, 0.83) | <0.001 |
| Model 2 | 1.0 (reference) | 0.92 (0.78, 1.08) | 0.89 (0.76, 1.05) | 0.81 (0.68, 0.96) | 0.80 (0.67, 0.95) | 0.02 |
| Model 3 | 1.0 (reference) | 0.95 (0.80, 1.13) | 1.00 (0.81, 1.23) | 0.94 (0.74, 1.19) | 0.92 (0.73, 1.16) | 0.52 |
| 4–8-y lag | ||||||
| No. of cases (n = 1249) | 270 | 262 | 256 | 226 | 235 | |
| Model 1 | 1.0 (reference) | 0.95 (0.80, 1.13) | 0.85 (0.72, 1.01) | 0.77 (0.64, 0.91) | 0.79 (0.67, 0.95) | 0.02 |
| Model 2 | 1.0 (reference) | 0.99 (0.83, 1.17) | 0.92 (0.77, 1.09) | 0.85 (0.71, 1.01) | 0.88 (0.74, 1.05) | 0.17 |
| Model 3 | 1.0 (reference) | 0.96 (0.80, 1.16) | 0.92 (0.75, 1.14) | 0.97 (0.75, 1.25) | 0.99 (0.78, 1.26) | 0.73 |
| 8–12-y lag | ||||||
| No. of cases (n = 1065) | 234 | 238 | 217 | 203 | 173 | |
| Model 1 | 1.0 (reference) | 0.99 (0.83, 1.19) | 0.84 (0.69, 1.01) | 0.80 (0.66, 0.97) | 0.68 (0.55, 0.83) | <0.001 |
| Model 2 | 1.0 (reference) | 1.03 (0.86, 1.24) | 0.89 (0.74, 1.08) | 0.89 (0.73, 1.08) | 0.75 (0.62, 0.92) | 0.002 |
| Model 3 | 1.0 (reference) | 1.10 (0.90, 1.34) | 1.03 (0.82, 1.29) | 1.09 (0.83, 1.44) | 0.92 (0.71, 1.21) | 0.17 |
| 12–16-y lag | ||||||
| No. of cases (n = 770) | 203 | 176 | 177 | 168 | 146 | |
| Model 1 | 1.0 (reference) | 0.82 (0.66, 1.02) | 0.75 (0.61, 0.93) | 0.77 (0.62, 0.96) | 0.66 (0.53, 0.83) | 0.004 |
| Model 2 | 1.0 (reference) | 0.85 (0.68, 1.06) | 0.79 (0.64, 0.98) | 0.85 (0.68, 1.06) | 0.74 (0.59, 0.92) | 0.045 |
| Model 3 | 1.0 (reference) | 0.91 (0.72, 1.15) | 0.89 (0.68, 1.15) | 1.04 (0.76, 1.42) | 0.93 (0.69, 1.26) | 0.71 |
Model 1 was adjusted for age (mo). Model 2 was adjusted as for model 1 and for smoking before age 30 y (0, 1–4, 5–10, or >10 pack-years), history of colorectal cancer in a parent or sibling (yes or no), history of endoscopy (yes or no), regular aspirin use (yes or no), BMI (in kg/m2; <25, 25 to <30, or ≥30), physical activity (<3, 3 to <27, or ≥27 metabolic equivalent task hours per week), and postmenopausal hormone use (premenopausal, never, past, or current user). Model 3 was adjusted as for model 2 and for consumption of processed meat (quintiles), alcohol consumption (0 to <5, 5 to <10, 10 to <15, or ≥15 g/d), energy-adjusted total calcium intake (quintiles), total folate (quintiles), total vitamin D intake (quintiles), and total energy intake (quintiles). P-trend values were calculated by using Wald's test.
RR; 95% CI in parentheses (all such values).