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Biochemical SIRT1 activation is not necessary for the induction of the stress proteome by 4PBA, HU, TSA and SFN. SIRT1 activity assay. SIRT1 activity was measured by incubating an acetylated lysine substrate with human recombinant SIRT1, cosubstrate NAD+ and the indicated concentration of each small molecule. The percent inhibition of SIRT1 is plotted. Bars = SEM for triplicate measurements. *P ≤ 0.05; paired t-test.
