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. 2012 Jul 5;21(19):4348–4355. doi: 10.1093/hmg/dds266

Figure 1.

Figure 1.

Cisplatin IC50 significantly correlates with the local eQTL rs17115814 and PRPF39 expression. (A) Genome-wide association results of 176 YRI LCLs were analyzed to identify local eQTLs at P< 0.01, defined as being within the gene, 2 kb of the 5′ end of the gene, or 0.5 kb of the 3′ end of the gene. Local eQTLs were then analyzed as to whether they were distant eQTLs for more than 10 target genes at P< 0.0001. Finally, the host gene's relationship was evaluated for correlation with cisplatin cytotoxicity at P< 0.05. Cisplatin IC50 is significantly correlated with rs17115814 with an empirical P= 9.99 × 10−5 (B) as well as with PRPF39 expression at P= 0.01 (C). The intronic SNP is associated with PRPF39 expression at P= 0.0007 (D).