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. 2012 Sep 11;3:315. doi: 10.3389/fmicb.2012.00315

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Copyright © 2012 Zhu, O’Dell, Ofek, Pancera, Wu, Zhang, Zhang, NISC Comparative Sequencing Program, Mullikin, Simek, Burton, Koff, Shapiro, Mascola and Kwong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Evolutionary similarity of PGT135–137 to donor 39 heavy-chain variable-domain sequences. Germline-rooted maximum-likelihood tree of PGT135–137 and 202 sequences identified by the iterative intra-donor phylogenetic analysis of donor 39 heavy-chain variable domain sequences determined by 454 pyrosequencing. The iterative intra-donor phylogenetic analysis was based on an implementation of neighbor-joining (NJ) method. Collapsed branches are indicated by Collapse {N: M}, in which N is the branch depth (number of intermediate nodes) and M is the number of sequences within the branch. All sequences are on the PGT137 branch except for 174091, which is somatically related to PGT136.