Figure 1.
IFNγ induces survival and/or proliferation of Stat1 deficient cells. (A and B) Ten million BMC obtained from Stat1−/− and WT mice were plated in the presence of medium, rM-CSF (50 ng/ml), IFNγ (14 ng/ml), IFNα (8.5 ng/ml), or different combinations of these cytokines. After 7 days, viable cells were counted. Shown are the total viable cells obtained in the presence (A) or absence (B) of M-CSF. The averages of five independent experiments are shown. (C) Total cells obtained after culturing 1 × 107 BMC for 7 days. The cytokines and growth factors used were: M-CSF (50 ng/ml); IFNγ (14 ng/ml); GM-CSF (5 ng/ml); and IL-3 (10 ng/ml). The averages of three independent experiments are shown.
