Table 1.
Genes regulated by IFNγ in the presence or absence of Stat1
| Mice | Regulation | Accession no. | Description | Average difference change | Fold change | Sort score |
|---|---|---|---|---|---|---|
| Wild-type | Induced | ab000677 | JAB/SOCS1 | 7,811 | ≈123.4 | 82.21 |
| m63961 | IFNγ inducible protein (mag-1) | 1,993 | ≈32.2 | 27.14 | ||
| m35590 | Macrophage inflammatory protein 1-β | 1,957 | ≈31.7 | 26.66 | ||
| m19681 | MCP-1 (JE) | 6,532 | 22 | 41.18 | ||
| y07711 | zyxin | 1,357 | ≈21.9 | 17.8 | ||
| M34815 | Monokine induced by IFNγ (MIG) | 1,214 | ≈20.0 | 15.87 | ||
| m33266 | Interferon inducible protein 10 (IP-10) | 14,853 | 19.5 | 58.24 | ||
| U44731 | Purine nucleotide binding protein | 2,285 | 17.4 | 21.42 | ||
| U88328 | Sup. of cytokine signalling-3 (SOCS-3) | 13,190 | 12.8 | 42.23 | ||
| M21065 | Interferon regulatory factor 1 | 6,096 | 11.1 | 14.51 | ||
| M63630 | GTP binding protein (IRG-47) | 1,700 | 9.8 | 12.34 | ||
| U19119 | G-protein-like LRG-47 | 5,529 | 9.5 | 21.81 | ||
| L27990 | Ro protein | 1,928 | 9.4 | 12.75 | ||
| M31419 | 204 interferon-activatable protein | 763 | 9.4 | 7.98 | ||
| af022371 | Interferon-inducible protein 203 | 3,770 | 9 | 17.21 | ||
| U28404 | MIP-1 alpha receptor | 754 | 8.7 | 7.41 | ||
| U43085 | Glucocorticoid-attenuated response 39 | 423 | ≈7.6 | 4.74 | ||
| x56123 | Talin | 575 | 7.1 | 5.35 | ||
| m31419 | 204 interferon-activatable protein | 3,730 | 7 | 13.46 | ||
| U53219 | GTPase IGTP | 5,600 | 6.7 | 15.87 | ||
| l38444 | T-cell specific protein | 1,282 | 6.5 | 7.36 | ||
| M31418 | 202 interferon-activatable protein | 6,697 | 6.4 | 16.48 | ||
| d38417 | Arylhydrocarbon receptor | 1,295 | 5.6 | 6.21 | ||
| m26071 | Tissue factor (mtf) | 359 | 5.1 | 2.93 | ||
| D13759 | Cot proto-oncogene | 1,277 | 4.7 | 4.91 | ||
| M18194 | Fibronectin | 5,686 | 4.5 | 10.03 | ||
| u59463 | ICH-3 | 1,146 | 4.4 | 4.32 | ||
| M13945 | pim-1 proto-oncogene | 856 | 4.3 | 3.57 | ||
| L20450 | DNA-binding protein | 447 | 4.2 | 2.51 | ||
| Repressed | j04596 | Platelet-derived growth factor-ind. KC | −1,302 | ≈−21.4 | −17.7 | |
| v00727 | c-fos oncogene | −805 | ≈−13.4 | −10.47 | ||
| U29088 | RNA binding protein Mel-N1 | −518 | ≈−9.1 | −5.66 | ||
| m84145 | Fumarylacetoacetate hydrolase | −365 | ≈−6.7 | −3.85 | ||
| X61940 | Growth factor-inducible 3CH134 | −576 | −5.5 | −4.03 | ||
| X53798 | Macrophage inflammatory protein-2 | −284 | ≈−5.4 | −2.76 | ||
| X89749 | mTGIF | −591 | −4.4 | −3.07 | ||
| X99581 | CXCR4 | −2,872 | −4 | −5.93 | ||
| Stat1−/− | Induced | m19681 | MCP-1 (JE) | 910 | ≈19.6 | 13.1 |
| U44088 | TDAG51 | 530 | ≈11.9 | 7.45 | ||
| u67321 | Lice2 cysteine protease | 322 | ≈7.6 | 2.57 | ||
| AF020194 | Retinal taurine transporter | 1,905 | 5.6 | 7.51 | ||
| aa155321 | PRP8 | 848 | 5 | 4.34 | ||
| aa217487 | PIM-1 proto-oncogene | 520 | 5 | 3.43 | ||
| M18194 | Fibronectin (FN) | 2,299 | 4.1 | 5.5 | ||
| U88328 | SOCS-3 | 4,380 | 4 | 7.23 | ||
| Repressed | j04181 | A-X actin | −1,547 | ≈−32.7 | −23.94 | |
| AA033408 | XPE UV-damaged DNA binding factor | −973 | ≈−20.9 | −15.03 | ||
| D50523 | TI-227 | −427 | −9.1 | −5.81 | ||
| AA590859 | Melanoma X actin | −9,743 | −8 | −24.83 | ||
| U17252 | Metabotropic glutamate receptor 8 | −590 | ≈−5.1 | −0.8 | ||
| M32309 | Zfx, zinc finger protein | −323 | −4.5 | −2.37 | ||
| M26391 | Retinoblastoma susceptibility protein | −466 | −4.2 | −2.57 |
Shown are a sampling of IFNγ-regulated genes with fold changes greater than or equal to 4. ≈, The value for this gene at time 0 was below the background and thus the calculation of the fold change is approximate.