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. 2012 Jul 2;10:135. doi: 10.1186/1479-5876-10-135

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Copyright ©2012 Liu et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Overall and disease-free survival curves assessed by Kaplan–Meier analysis according to HMGB1 expression and tumor size. (a) Overall survival. High expression of HMGB1 predicted poorer overall survival only for tumor >5 cm (group 3 VS group 4; p = 0.031); but not for tumor ≤5 cm (group 1 VS group 2; p = 0.101). (b) Disease-free survival. High expression of HMGB1 predict poor disease-free survival only for tumor >5 cm (group 3 VS group 4; p = 0.012); but not for tumor ≤5 cm (group 1 VS group 2; p = 0.087). Group 1, tumor ≤5 cm/ HMGB1 low expression (n = 49); group 2, tumor ≤5 cm/ HMGB1 high expression (n = 36); group 3, tumor >5 cm/ HMGB1 low expression (n = 43); group 4, tumor >5 cm/ HMGB1 high expression (n = 33).