Table 1.
Variables | All Patients (n = 161) | High HMGB1 (n = 69) | Low HMGB1 (n = 92) | Pvalue |
---|---|---|---|---|
Age(mean ± SD, year) |
46.1 ± 11.5 |
44.9 ± 11.6 |
48.1 ± 11.3 |
0.511 |
≤55 |
128 |
59 |
69 |
0.103 |
>55 |
33 |
10 |
23 |
|
Gender |
0.639 |
|||
Male |
140 |
61 |
79 |
|
Female |
21 |
8 |
13 |
|
HBV infection |
0.377 |
|||
Absent |
17 |
9 |
8 |
|
Present |
144 |
60 |
84 |
|
AFP level |
0.785 |
|||
≤400 ng/ml |
89 |
39 |
50 |
|
>400 ng/ml |
72 |
30 |
42 |
|
Liver cirrhosis |
|
|||
Absent |
22 |
9 |
13 |
|
Present |
139 |
60 |
79 |
|
Child-pugh |
0.403 |
|||
A |
158 |
67 |
91 |
|
B |
3 |
2 |
1 |
|
Tumor size(mean ± SD, cm) |
6.3 ± 4.1 |
6.0 ± 3.6 |
6.5 ± 4.5 |
0.075 |
≤5 cm |
85 |
36 |
49 |
0.892 |
>5 cm |
76 |
33 |
43 |
|
Tumor number |
|
|
|
|
Single |
147 |
62 |
85 |
0.575 |
2-3 |
14 |
7 |
7 |
|
Tumor encapsulation |
|
|
|
0.035 |
Complete |
71 |
37 |
34 |
|
Incomplete |
90 |
32 |
58 |
|
TNM stage |
|
|
|
0.036 |
I |
131 |
51 |
80 |
|
II-III |
30 |
18 |
12 |
|
Tumor differentiation |
|
|
|
|
I-II |
67 |
23 |
44 |
0.066 |
III-IV | 94 | 46 | 48 |
HBV: hepatitis B virus, AFP: alpha fetoprotein, HMGB1: high mobility group box 1.