Table 1.
Correlations between HMGB1 expression and clinicopathalogic characteristics in 161 patients with HCC
| Variables | All Patients (n = 161) | High HMGB1 (n = 69) | Low HMGB1 (n = 92) | Pvalue |
|---|---|---|---|---|
| Age(mean ± SD, year) |
46.1 ± 11.5 |
44.9 ± 11.6 |
48.1 ± 11.3 |
0.511 |
| ≤55 |
128 |
59 |
69 |
0.103 |
| >55 |
33 |
10 |
23 |
|
| Gender |
0.639 |
|||
| Male |
140 |
61 |
79 |
|
| Female |
21 |
8 |
13 |
|
| HBV infection |
0.377 |
|||
| Absent |
17 |
9 |
8 |
|
| Present |
144 |
60 |
84 |
|
| AFP level |
0.785 |
|||
| ≤400 ng/ml |
89 |
39 |
50 |
|
| >400 ng/ml |
72 |
30 |
42 |
|
| Liver cirrhosis |
|
|||
| Absent |
22 |
9 |
13 |
|
| Present |
139 |
60 |
79 |
|
| Child-pugh |
0.403 |
|||
| A |
158 |
67 |
91 |
|
| B |
3 |
2 |
1 |
|
| Tumor size(mean ± SD, cm) |
6.3 ± 4.1 |
6.0 ± 3.6 |
6.5 ± 4.5 |
0.075 |
| ≤5 cm |
85 |
36 |
49 |
0.892 |
| >5 cm |
76 |
33 |
43 |
|
| Tumor number |
|
|
|
|
| Single |
147 |
62 |
85 |
0.575 |
| 2-3 |
14 |
7 |
7 |
|
| Tumor encapsulation |
|
|
|
0.035 |
| Complete |
71 |
37 |
34 |
|
| Incomplete |
90 |
32 |
58 |
|
| TNM stage |
|
|
|
0.036 |
| I |
131 |
51 |
80 |
|
| II-III |
30 |
18 |
12 |
|
| Tumor differentiation |
|
|
|
|
| I-II |
67 |
23 |
44 |
0.066 |
| III-IV | 94 | 46 | 48 | |
HBV: hepatitis B virus, AFP: alpha fetoprotein, HMGB1: high mobility group box 1.