Table 2.
Univariate and Multivariate analyses of overall and disease-free survival for 161 HCC patients
|
Variables |
Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|
| Chi-Square (χ2) | P value | HR (95% CI) | P value | |
|
Overall survival |
|
|
|
|
| Age(≤55y vs >55y) |
0.453 |
0.501 |
|
|
| Gender(male vs female) |
1.875 |
0.171 |
|
|
| HBV infection(absent vs present) |
0.011 |
0.915 |
|
|
| AFP level(≤400 ng/ml vs >400 ng/ml) |
0.170 |
0.680 |
|
|
| Liver cirrhosis(absent vs present) |
1.631 |
0.202 |
|
|
| Child-pugh(A vs B) |
0.158 |
0.691 |
|
|
| Tumor size(≤5 cm vs >5 cm) |
7.962 |
0.005 |
1.902(1.209-2.992) |
0.005 |
| Tumor number(single vs multipule) |
8.763 |
0.003 |
0.601(0.240-1.504) |
0.277 |
| Tumor encapsulation(complete vs incomplete) |
2.590 |
0.108 |
|
|
| TNM stage(I-II vs III) |
8.484 |
0.004 |
1.567(0.771-3.184) |
0.215 |
| Tumor differentiation(I-II vs III-IV) |
0.033 |
0.856 |
|
|
| HMGB1(low vs high) |
7.022 |
0.008 |
1.834(1.167-2.881) |
0.009 |
|
Disease-free survival |
|
|
|
|
| Age(≤55y vs >55y) |
0.812 |
0.367 |
|
|
| Gender(male vs female) |
0.120 |
0.729 |
|
|
| HBV infection (absent vs present) |
0.118 |
0.731 |
|
|
| AFP level(≤400 ng/ml vs >400 ng/ml) |
0.748 |
0.387 |
|
|
| Liver cirrhosis(absent vs present) |
1.972 |
0.160 |
|
|
| Child-pugh(A vs B) |
1.502 |
0.220 |
|
|
| Tumor size(≤5 cm vs >5 cm) |
8.367 |
0.004 |
1.661(1.119-2.465) |
0.012 |
| Tumor number(single vs multipule) |
14.484 |
<0.001 |
0.484(0.218-1.071) |
0.073 |
| Tumor encapsulation(complete vs incomplete) |
6.531 |
0.011 |
0.739(0.497-1.099) |
0.136 |
| TNM stage(I-II vs III) |
11.494 |
0.001 |
1.314(0.719-2.402) |
0.374 |
| Tumor differentiation(I-II vs III-IV) |
3.062 |
0.080 |
1.252(1.088-2.419) |
0.291 |
| HMGB1(low vs high) | 8.176 | 0.004 | 1.622(1.088-2.419) | 0.018 |
HBV: hepatitis B virus, AFP: alpha fetoprotein, HMGB1: high mobility group box 1, HR: Hazard Ratio.