Figure 1.

Dynamic contrast-enhanced MRI of experimental prostate cancer. Following dynamic contrast-enhanced (DCE) MRI the tumors were traced in the T₁-weighted images. Firstly, semi-quantitative analysis was performed on the time-dependent relative signal intensity (RSI(t)) curves, by calculating the area under the RSI curve (AUC(t)), of each tumor voxel, for different time-points. Secondly, pharmacokinetic analysis was performed using the Tofts model, producing parametric tumor maps of K^trans, k_ep, and V_e. Examples of parametric tumor maps are shown to the right.