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. 2012 May 23;7:75. doi: 10.1186/1748-717X-7-75

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Copyright ©2012 Røe et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Semi-quantitative and pharmacokinetic analysis of dynamic contrast-enhanced MRI. Both semi-quantitative and pharmacokinetic DCE MRI parameters unveiled increased vascularization in androgen-deprived (AD) tumors. Intergroup differences between untreated (Ctrl), irradiated (RT), and androgen-deprived (AD) prostate carcinoma (PC) xenografts for the semi-quantitative parameter area under the relative signal intensity curve ( AUC) (a.u.) for 1 min ( A), 5 min ( B), 10 min ( C), and 20 min ( D), and Tofts kinetic model parameters K^trans (s^-1) (E), k_ep (s^-1) (F), and V_e (a.u.) (G), in addition to the fraction of unfitted voxels (H), summarized as mean and s.e.m. per group. Significant differences (p < 0.05) compared to Ctrl tumors are indicated with a *.