Table 1.
Genes upregulated in the total RNA fraction in the presence of wild-type and mutant Tax proteins
|
Gene ID |
Gene description |
Gene Symbol |
Fold Change |
||
|---|---|---|---|---|---|
| TaxWT | TaxS240P | TaxD24G | |||
| |
Transcription/Translation/RNA processing |
|
|
|
|
| 1390 |
cAMP responsive element modulator |
CREM |
2.2 |
1.8 |
3.2 |
| 1958 |
early growth response 1 |
EGR1 |
1.9 |
2.0 |
1.7 |
| 22936 |
elongation factor, RNA polymerase II, 2 |
ELL2 |
2.2 |
2.2 |
2.2 |
| 2119 |
ets variant 5 |
ETV5 |
3.7 |
3.6 |
3.4 |
| 2353 |
FBJ murine osteosarcoma viral oncogene homolog |
FOS |
3.7 |
2.4 |
4.6 |
| 8061 |
FOS-like antigen 1 |
FOSL1 |
2.4 |
2.4 |
2.3 |
| 3280 |
Hairy and enhancer of split 1 (Drosophila) |
HES1 |
1.8 |
1.9 |
2.0 |
| 3725 |
jun oncogene |
JUN |
4.7 |
5.9 |
5.3 |
| 10365 |
Kruppel-like factor 2 (lung) |
KLF2 |
2.6 |
2.6 |
2.8 |
| 1316 |
Kruppel-like factor 6 |
KLF6 |
2.1 |
2.1 |
2.1 |
| 9935 |
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) |
MAFB |
2.6 |
1.9 |
3.8 |
| 23764 |
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) |
MAFF |
2.4 |
1.9 |
2.6 |
| 4929 |
nuclear receptor subfamily 4, group A, member 2 |
NR4A2 |
3.6 |
1.5 |
7.7 |
| 57157 |
Putative homeodomain transcription factor 2 |
PHTF2 |
1.9 |
1.9 |
2.0 |
| 6095 |
RAR-related orphan receptor A |
RORA |
10.3 |
2.0 |
10.6 |
| 7538 |
zinc finger protein 36, C3H type, homolog (mouse) |
ZFP36 |
2.8 |
2.6 |
2.6 |
| |
Signal Transduction |
|
|
|
|
| 287 |
ankyrin 2, neuronal |
ANK2 |
2.0 |
2.0 |
1.4 |
| 9518 |
growth differentiation factor 15 |
GDF15 |
5.0 |
4.9 |
5.6 |
| 2669 |
GTP binding protein over expressed in skeletal muscle |
GEM |
14.3 |
5.0 |
19.1 |
| 10681 |
guanine nucleotide binding protein (G protein), beta 5 |
GNB5 |
2.0 |
1.2 |
2.4 |
| 2786 |
guanine nucleotide binding protein (G protein), gamma 4 |
GNG4 |
1.8 |
2.0 |
1.6 |
| 26207 |
phosphatidylinositol transfer protein, cytoplasmic 1 |
PITPNC1 |
1.9 |
1.7 |
2.5 |
| 5329 |
plasminogen activator, urokinase receptor |
PLAUR |
2.0 |
1.7 |
1.9 |
| 5521 |
protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform |
PPP2R2B |
1.3 |
1.0 |
2.1 |
| 5997 |
regulator of G-protein signaling 2, 24 kDa |
RGS2 |
2.4 |
1.1 |
2.4 |
| 6004 |
regulator of G-protein signaling 16 |
RGS16 |
2.0 |
2.0 |
2.0 |
| 6236 |
Ras-related associated with diabetes |
RRAD |
3.8 |
2.3 |
7.9 |
| 81848 |
sprouty homolog 4 (Drosophila) |
SPRY4 |
1.9 |
2.1 |
1.9 |
| |
Inflammatory response/Immune response |
|
|
|
|
| 2921 |
chemokine (C-X-C motif) ligand 3 |
CXCL3 |
1.8 |
2.0 |
1.8 |
| 3269 |
histamine receptor H1 |
HRH1 |
2.5 |
1.7 |
1.8 |
| 7130 |
tumor necrosis factor, alpha-induced protein 6 |
TNFAIP6 |
20.5 |
1.3 |
36.6 |
| |
Regulation of cell growth/Regulation of cell proliferation |
|
|
|
|
| 183 |
angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
AGT |
1.3 |
1.3 |
2.3 |
| 374 |
amphiregulin |
AREG |
2.0 |
2.1 |
2.3 |
| 694 |
B-cell translocation gene 1, anti-proliferative |
BTG1 |
3.3 |
1.1 |
3.0 |
| 6347 |
chemokine (C-C motif) ligand 2 |
CCL2 |
2.0 |
1.6 |
1.6 |
| 960 |
CD44 molecule (Indian blood group) |
CD44 |
2.1 |
2.0 |
2.3 |
| 3491 |
cysteine-rich, angiogenic inducer, 61 |
CYR61 |
4.8 |
2.0 |
7.5 |
| 2014 |
epithelial membrane protein 3 |
EMP3 |
1.8 |
1.2 |
3.1 |
| 3589 |
interleukin 11 |
IL11 |
3.6 |
1.7 |
5.4 |
| 83729 |
inhibin, beta E |
INHBE |
2.1 |
3.0 |
1.9 |
| 182 |
jagged 1 |
JAG1 |
2.1 |
1.8 |
2.3 |
| 3976 |
leukemia inhibitory factor (cholinergic differentiation factor) |
LIF |
2.2 |
2.2 |
2.2 |
| |
Apoptosis |
|
|
|
|
| 56892 |
chromosome 8 open reading frame 4 |
C8orf4 |
1.2 |
1.2 |
2.3 |
| 8870 |
immediate early response 3 |
IER3 |
3.3 |
3.2 |
3.7 |
| 22822 |
pleckstrin homology-like domain, family A, member 1 |
PHLDA1 |
2.5 |
1.9 |
3.2 |
| 51330 |
tumor necrosis factor receptor superfamily, member 12A |
TNFRSF12A |
2.0 |
1.9 |
2.0 |
| 27242 |
tumor necrosis factor receptor superfamily, member 21 |
TNFRSF21 |
2.3 |
2.1 |
2.4 |
| |
Cell adhesion/Cell-cell adhesion |
|
|
|
|
| 6695 |
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 |
SPOCK1 |
2.0 |
1.7 |
2.1 |
| 6696 |
secreted phosphoprotein 1 |
SPP1 |
1.9 |
2.5 |
2.1 |
| |
Transport |
|
|
|
|
| 3039 |
hemoglobin, alpha 1 |
HBA1 |
2.4 |
2.5 |
2.4 |
| 4884 |
neuronal pentraxin I |
NPTX1 |
2.3 |
1.2 |
3.6 |
| 6507 |
solute carrier family 1, member 3 |
SLC1A3 |
1.8 |
2.0 |
1.8 |
| 6533 |
solute carrier family 6, member 6 |
SLC6A6 |
2.2 |
2.3 |
1.9 |
| 23657 |
solute carrier family 7, member 11 |
SLC7A11 |
2.3 |
2.4 |
1.8 |
| |
Metabolic process |
|
|
|
|
| 384 |
arginase, type II |
ARG2 |
3.2 |
3.2 |
3.6 |
| 9945 |
glutamine-fructose-6-phosphate transaminase 2 |
GFPT2 |
2.0 |
2.0 |
1.9 |
| 9388 |
Lipase, endothelial |
LIPG |
1.9 |
1.4 |
2.1 |
| 7378 |
uridine phosphorylase 1 |
UPP1 |
2.1 |
1.8 |
2.0 |
| |
Phosphorylation/Dephosphorylation |
|
|
|
|
| 9201 |
doublecortin-like kinase 1 |
DCLK1 |
2.1 |
2.0 |
2.1 |
| 1843 |
dual specificity phosphatase 1 |
DUSP1 |
3.6 |
2.4 |
4.7 |
| 51207 |
dual specificity phosphatase 13 |
DUSP13 |
2.2 |
1.9 |
2.2 |
| 1846 |
dual specificity phosphatase 4 |
DUSP4 |
2.9 |
3.0 |
2.9 |
| 1847 |
dual specificity phosphatase 5 |
DUSP5 |
2.4 |
2.4 |
2.8 |
| 1848 |
dual specificity phosphatase 6 |
DUSP6 |
2.4 |
2.8 |
2.7 |
| 5578 |
protein kinase C, alpha |
PRKCA |
2.1 |
1.9 |
1.8 |
| |
Response to stress |
|
|
|
|
| 3337 |
DnaJ (Hsp40) homolog, subfamily B, member 1 |
DNAJB1 |
2.7 |
3.1 |
2.5 |
| 3303 |
heat shock 70 kDa protein 1A |
HSPA1A |
2.9 |
4.2 |
2.8 |
| 3310 |
heat shock 70 kDa protein 6 |
HSPA6 |
6.4 |
15.4 |
5.3 |
| |
Others/Unknown |
|
|
|
|
| 202 |
absent in melanoma 1 |
AIM1 |
1.7 |
1.8 |
2.1 |
| 23237 |
activity-regulated cytoskeleton-associated protein |
ARC |
2.5 |
2.3 |
2.3 |
| 1475 |
cystatin A (stefin A) |
CSTA |
4.6 |
5.3 |
5.4 |
| 56603 |
cytochrome P450, family 26, subfamily B, polypeptide 1 |
CYP26B1 |
2.1 |
1.7 |
2.1 |
| 23052 |
endonuclease domain containing 1 |
ENDOD1 |
2.0 |
2.1 |
2.1 |
| 2201 |
fibrillin 2 |
FBN2 |
2.1 |
1.6 |
1.8 |
| 10324 |
kelch repeat and BTB (POZ) domain containing 10 |
KBTBD10 |
3.0 |
1.9 |
2.4 |
| 5270 |
serpin peptidase inhibitor, clade E, member 2 |
SERPINE2 |
2.3 |
2.3 |
2.4 |
| 4071 |
transmembrane 4 L six family member 1 |
TM4SF1 |
1.9 |
1.8 |
2.3 |
| 25907 |
transmembrane protein 158 (gene/pseudogene) |
TMEM158 |
2.1 |
2.4 |
2.5 |
| 7171 |
tropomysin 4 |
TPM4 |
2.5 |
1.5 |
3.5 |
| 7846 | tubulin, alpha 1a | TUBA1A | 1.9 | 2.1 | 1.8 |