Table 2.
Genes downregulated in the total RNA fraction in the presence of wild-type and mutant Tax proteins
|
Gene ID |
Gene description |
Gene Symbol |
Fold Change |
||
|---|---|---|---|---|---|
| TaxWT | TaxS240P | TaxD247G | |||
| |
Transcription/Translation/RNA processing |
|
|
|
|
| 23741 |
EP300 interacting inhibitor of differentiation 1 |
EID1 |
2.0 |
2.1 |
2.0 |
| 2625 |
GATA binding protein 3 |
GATA3 |
2.0 |
1.6 |
1.6 |
| 3398 |
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
ID2 |
1.6 |
1.4 |
2.2 |
| 23658 |
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
LSM5 |
1.7 |
1.8 |
2.0 |
| 63931 |
mitochondrial ribosomal protein S14 |
MRPS14 |
1.9 |
2.4 |
2.2 |
| 5936 |
RNA binding motif protein 4 |
RBM4 |
1.7 |
2.4 |
2.1 |
| 6591 |
snail homolog 2 (Drosophila) |
SNAI2 |
1.9 |
2.2 |
1.7 |
| |
Immune response/Response to virus |
|
|
|
|
| 23586 |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 |
DDX58 |
2.9 |
3.3 |
3.9 |
| 79132 |
DEXH (Asp-Glu-X-His) box polypeptide 58 |
DHX58 |
2.1 |
2.2 |
2.3 |
| 10561 |
interferon-induced protein 44 |
IFI44 |
2.1 |
2.7 |
2.8 |
| 64135 |
interferon induced with helicase C domain 1 |
IFIH1 |
2.0 |
2.2 |
2.3 |
| 3434 |
interferon-induced protein with tetratricopeptide repeats 1 |
IFIT1 |
5.2 |
5.6 |
6.0 |
| 3433 |
interferon-induced protein with tetratricopeptide repeats 2 |
IFIT2 |
3.1 |
3.7 |
4.2 |
| 3437 |
interferon-induced protein with tetratricopeptide repeats 3 |
IFIT3 |
5.4 |
5.5 |
5.5 |
| 9636 |
ISG15 ubiquitin-like modifier |
ISG15 |
2.2 |
2.6 |
2.1 |
| 8638 |
2'-5'-oligoadenylate synthetase-like |
OASL |
8.8 |
8.8 |
10.3 |
| 445347 |
TCR gamma alternate reading frame protein |
TARP |
1.9 |
3.0 |
1.1 |
| 6967 |
T cell receptor gamma constant 2 |
TRGC2 |
2.1 |
3.4 |
1.2 |
| 56829 |
zinc finger CCCH-type, antiviral 1 |
ZC3HAV1 |
2.9 |
2.9 |
3.2 |
| |
Cell signalling |
|
|
|
|
| 3641 |
insulin-like 4 (placenta) |
INSL4 |
2.4 |
2.7 |
2.5 |
| 5122 |
proprotein convertase subtilisin/kexin type 1 |
PCSK1 |
2.8 |
2.8 |
2.5 |
| 25780 |
RAS guanyl releasing protein 3 (calcium and DAG-regulated) |
RASGRP3 |
1.6 |
2.1 |
1.8 |
| |
Nucleosome assembly |
|
|
|
|
| 94239 |
H2A histone family, member V |
H2AFV |
1.9 |
2.0 |
1.9 |
| 8334 |
histone cluster 1, H2ac |
HIST1H2AC |
2.1 |
2.0 |
2.0 |
| 8329 |
histone cluster 1, H2ag |
HIST1H2AG |
1.6 |
2.2 |
1.7 |
| 8349 |
histone cluster 2, H2be |
HIST2H2BE |
1.7 |
2.2 |
1.6 |
| |
Regulation of cell proliferation |
|
|
|
|
| 2247 |
fibroblast growth factor 2 (basic) |
FGF2 |
3.4 |
3.5 |
3.7 |
| 10216 |
proteoglycan 4 |
PRG4 |
1.7 |
2.2 |
1.7 |
| 5920 |
retinoic acid receptor responder (tazarotene induced) 3 |
RARRES3 |
2.3 |
2.4 |
2.5 |
| |
Apoptosis |
|
|
|
|
| 8743 |
tumor necrosis factor (ligand) superfamily, member 10 |
TNFSF10 |
2.5 |
2.9 |
2.6 |
| |
Cell cycle |
|
|
|
|
| 10083 |
Usher syndrome 1 C (autosomal recessive, severe) |
USH1C |
2.0 |
2.0 |
1.7 |
| |
Transport |
|
|
|
|
| 57101 |
anoctamin 2 |
ANO2 |
1.9 |
2.1 |
2.0 |
| 6337 |
sodium channel, nonvoltage-gated 1 alpha |
SCNN1A |
2.4 |
2.1 |
2.4 |
| 6717 |
sorcin |
SRI |
2.3 |
2.3 |
2.6 |
| |
Ubiquitin |
|
|
|
|
| 51191 |
hect domain and RLD 5 |
HERC5 |
4.9 |
5.0 |
5.7 |
| 55008 |
hect domain and RLD 6 |
HERC6 |
2.2 |
2.5 |
2.2 |
| |
Others/Unknown |
|
|
|
|
| 83990 |
BRCA1 interacting protein C-terminal helicase 1 |
BRIP1 |
1.4 |
2.1 |
1.8 |
| 79940 |
chromosome 6 open reading frame 155 |
C6orf155 |
1.5 |
2.1 |
1.5 |
| 1601 |
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) |
DAB2 |
2.2 |
2.3 |
2.2 |
| 55601 |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 |
DDX60 |
3.7 |
4.1 |
4.3 |
| 2335 |
fibronectin 1 |
FN1 |
2.0 |
2.5 |
1.8 |
| 23387 |
SIK family kinase 3 |
KIAA0999 |
1.2 |
1.2 |
2.2 |
| 54809 |
sterile alpha motif domain containing 9 |
SAMD9 |
1.8 |
2.0 |
2.4 |
| 6414 |
selenoprotein P, plasma, 1 |
SEPP1 |
2.1 |
2.1 |
2.2 |
| 8470 | sorbin and SH3 domain containing 2 | SORBS2 | 2.2 | 2.4 | 2.4 |