Table 3.
Genes involved in signaling pathways regulated by wild-type and mutant Tax proteins (p < 0.05)*
| Significant Pathway | TaxWT | TaxS240P | TaxD247G |
|---|---|---|---|
| Direct p53 effectors |
DUSP1, DUSP5, GDF15, HSPA1A, JUN, LIF |
BDKRB2, DUSP1, DUSP5, GDF15, HSPA1A, JUN, LIF, SNAI2, SPP1 |
DUSP1, DUSP5, GDF15, HSPA1A, JUN, LIF, SPP1 |
| Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
FOS, FOSL1, GATA3, JUN, LIF, PLAUR |
FOS, FOSL1, IL8, JUN, LIF |
FOS, FOSL1, JUN, LIF |
| IL1-mediated signaling events |
DUSP1, FOS, FOSL1, GATA3, JUN |
DUSP1, FOS, FOSL1, IL8, JUN |
DUSP1, FOS, FOSL1, JUN |
| BMP receptor signalling |
DUSP1, FOS, FOSL1, GATA3, JUN |
DUSP1, FOS, FOSL1, IL8, JUN |
DUSP1, FOS, FOSL1, JUN |
| p38 MAPK signaling pathway |
DUSP1, FOS, FOSL1, GATA3, JUN |
DUSP1, FOS, FOSL1, IL8, JUN |
DUSP1, FOS, FOSL1, JUN |
| Regulation of p38-alpha and p38-beta |
DUSP1, FOS, FOSL1, GATA3, JUN |
DUSP1, FOS, FOSL1, IL8, JUN |
DUSP1, FOS, FOSL1, JUN |
| IL12-mediated signaling events |
ETV5, FOS, GATA3, JUN |
ETV5, FOS, IL12A, JUN |
ETV5, FOS, JUN |
| Role of Calcineurin-dependent NFAT signaling in lymphocytes |
FOS, FOSL1, GATA3, JUN |
FOS, FOSL1, IL8, JUN |
FOS, FOSL1, JUN |
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
FOS, FOSL1, GATA3, JUN |
FOS, FOSL1, IL8, JUN |
FOS, FOSL1, JUN |
| FOXM1 transcription factor network |
ETV5, FOS, HSPA1A |
ETV5, FOS, HSPA1A |
ETV5, FOS, HSPA1A |
| xef;ve CD4+ T cells |
FOS, FOSL1, JUN |
FOS, FOSL1, JUN |
FOS, FOSL1, JUN |
| CXCR4-mediated signaling events |
FOS, FOSL1, JUN |
FOS, FOSL1, JUN |
FOS, FOSL1, JUN |
| Glucocorticoid receptor signaling |
FOS, GATA3, JUN |
FOS, IL8, JUN |
|
| ATF-2 transcription factor network |
DUSP1, DUSP5, JUN |
DUSP1, DUSP5, IL8, JUN |
DUSP1, DUSP5, HES1, JUN |
| JNK signaling in the CD4+ TCR pathway |
FOSL1, JUN |
FOS, FOSL1, JUN |
FOS, FOSL1, JUN |
| Ras signaling in the CD4+ TCR pathway |
FOS, FOSL1, JUN |
FOS, FOSL1, JUN |
FOS, FOSL1, JUN |
| xef;ve CD8+ T cells |
FOS, FOSL1, JUN |
FOS, FOSL1, JUN |
FOS, FOSL1, JUN |
| Calcium signaling in the CD4+ TCR pathway |
FOS, FOSL1, JUN |
FOS, FOSL1, JUN |
FOS, FOSL1, JUN |
| Regulation of Wnt-mediated beta catenin signaling and target gene transcription |
CYR61, JUN |
IL8, JUN, SNAI2 |
CYR61, ID2, JUN |
| IL2-mediated signaling events |
FOS, JUN |
FOS, JUN |
FOS, JUN |
| ErbB2/ErbB3 signaling events |
FOS JUN |
FOS, JUN |
FOS, JUN |
| BCR signaling pathway |
FOS, JUN |
FOS, JUN |
FOS, JUN |
| IL12 signaling mediated by STAT4 |
ETV5, JUN |
ETV5, JUN |
ETV5, JUN |
| PDGFR-alpha signaling pathway |
FOS, JUN |
FOS, JUN |
FOS, JUN |
| Integrins in angiogenesis |
CD44, FGF2 |
CD44, FGF2, SPP1 |
CD44, FGF2, SPP1 |
| amb2 Integrin signalling | CYR61, PLAUR |
*Up- or downregulated genes are represented by regular or italic characters, respectively.