Table 1.

Parasitological parameters of animals subjected to different treatment schemes using biotherapic (BIOT_Tc17dH)

GROUP	AUC (x105)	Ptotal(x106)	Pmax(x106)	DAY OFPmax	P8thDI(x106)	2nd Pmax(x104)	DAY OF 2nd PEAK	2nd PEAK n/N (%)
CI	10.9±8.20	12.5±8.98	5.02±7.07	10.76±3.15	2.82±3.12	11.0±10.2	14.03±2.63	8/12 (66%)
BIOT4-5-6	9.23±3.26	9.33±3.25	5.82±2.14**	8.25±0.67**	5.11±2.62	2.10±17.4	12.0±2.0*	4/12 (33%)
BIOT7-8-9	8.78±2.34	9.32±2.48	4.05±2.42	8.64±0.71**	3.96±2.51	17.4±0	14.25±1.02	8/12 (66%)
BIOTPI	5.95±4.55**	6.63±5.02**	2.25±1.65**	15.46±23.06	1.62±1.69	11.1±13.6	13.67±0.63*	6/12 (50%)
BIOT4PI	4.28±2.89**	4.63±3.19**	1.45±1.00**	10.27±2.03	1.01±0.96	7.09±10.2	12.8±0.68*	6/12 (50%)

Statistical significance (p < 0.05* and p < 0.01**) compared to control group: CI: control group – infected animals treated with 7% ethanol-water solution diluted in water (10μL/mL) offered ad libitum; BIOT_PI: infected animals treated with biotherapic BIOT_Tc17dH diluted in water (10μL/mL) offered ad libitum from the day of the infection until the death of the animals; BIOT_4PI: infected animals treated with biotherapic BIOT_{Tc 17dH} diluted in water (10μL/mL) offered ad libitum from the 4^th day of the infection until the death of the animals; BIOT_4-5–6: infected animals treated with biotherapic BIOT_{TC 17dH} by gavage on the 4^th, 5^th and 6^th day of the infection; BIOT_7-8–9: infected animals treated with biotherapic BIOT_{TC 17dH} by gavage on the 7^th, 8^th and 9^th day of the infection. AUC = area under the curve (parasites/ mL); P_total = total parasitemia (parasites/ mL); P_max = maximum peak of parasites (parasites/ mL); Day of P_max = Day of maximum peak of parasites; P_8thDI = number of tripomastigotes on 8^th day of infection (parasites/ mL); 2^nd P_max = number of tripomastigotes in the 2^nd peak of parasites (parasites/ mL); Day of 2^nd P_max = Day of 2^nd peak of parasites; 2^ndPEAK n/N = number of animals that showed 2^nd peak of parasites (n)/ total number of infected animals (N) x 100.