Table 1.
Baseline characteristics of severe sepsis patients and control subjects
| Control n = 33 | Study Patients n = 67 | p value | |
|---|---|---|---|
|
Age (y) (mean±SD) |
66.3± 8.0 |
64.8± 13.8 |
0.57 |
|
Male (%) |
66.7 |
65.7 |
1.00 |
|
Underlying diseases |
|
|
|
|
Diabetes mellitus (%) |
54.5 |
35.8 |
0.09 |
|
Hypertension (%) |
60.6 |
44.8 |
0.20 |
|
Cardiac disease (%) |
12.1 |
11.9 |
1.00 |
|
Systolic blood pressure (mmHg) (mean±SD) |
143±15.2 |
112.2±42.3 |
<0.001 |
|
Diastolic blood pressure (mmHg) (mean±SD) |
76.5±10.1 |
70.5±24.2 |
0.09 |
|
Laboratory data† |
|
|
|
|
Mean (SD) WBC (×109/L) |
6.8 (2.5) |
15.9 (10.7) |
<0.001 |
|
Mean (SD) Platelet (×104/L) |
234.4 (66.4) |
158.2 (94.4) |
<0.001 |
|
Mean (SD) Hemoglobin(mg/dL) |
13.6 (1.7) |
11.9 (2.2) |
<0.001 |
|
Mean (SD) CRP (mg/dL) |
1.2 (0.9) |
189.6 (124.8) |
<0.001 |
|
Median (IQR) plasma nuclear DNA (ng/mL) |
25 (19,41) |
436 (216,1140) |
<0.001 |
| Median(IQR) plasma mitochondrial DNA ( ng/mL) | 16 (7,23) | 149 (79,304) | <0.001 |
Note: SD, standard deviation; IQR, inter-quartile range; †, laboratory data at presentation in the patients group.