Table 1.
Pharmacokinetic parameters for uric acid and lithium after oral administration of ATP
| Mode of administration (time period) | AUC uric acid mmol.min/L | Cmaxmmol/L (range) | tmaxmin (range) | AUC Lithium mmol.min |
|---|---|---|---|---|
| Naso-duodenal tube | ||||
| ATP (270 min) |
19.6 ± 4.4 a,b,c |
0.31 ± 0.03 |
135 |
n.a. |
| |
|
(0.23-0.38) |
(105–240) |
|
| Placebo (270 min) |
−0.4 ± 0.4 |
0.21 ± 0.03 |
n.a. |
n.a. |
| |
|
(0.15-0.33) |
|
|
| Proximal-release pellets |
|
|
|
|
| ATP (270 min) |
16.1 ± 3.0 |
n.a. |
n.a. |
n.a. |
| Placebo (270 min) |
0.8 ± 0.9 |
n.a. |
n.a. |
n.a. |
| ATP (420 min) |
25.4 ± 5.7 d,e |
0.30 ± 0.03 |
240 |
65174 ± 7985 f |
| |
|
(0.21-0.41) |
(165–390) |
|
| Placebo (420 min) |
0.9 ± 1.1 |
0.20 ± 0.02 |
n.a. |
117914 ± 15021 f |
| |
|
(0.16-0.31) |
|
|
| Distal-release pellets |
|
|
|
|
| ATP (270 min) |
1.7 ± 1.1 |
n.a. |
n.a. |
n.a. |
| ATP (420 min) |
3.2 ± 1.4 |
0.22 ± 0.02 |
390 |
12575 ± 2832 f |
| (0.17-0.34) | (105–420) | |||
Values are group means ± SEM, n = 8 per formulation, P-values are based on paired-samples t-tests. N.a. = not available.
a Different from naso-duodenal tube placebo (P = 0.002), b Different from ATP distal-release pellets 270 min (P = 0.007), c Different from proximal-release placebo pellets 270 min (P = 0.007) d Different from ATP distal release pellets 420 min (P = 0.005), e Different from proximal-release placebo pellets (P = 0.005), f Different from each other (P < 0.001).