Table 1.

Staging of SI-NENs according to histological and PCR-based analyses

	H&E Node positive	PCR Node positive	Percent upstaged by PCR
No Distant Metastases	6 / 9	8 / 9	22%*
Distant Metastases	11 / 12	12 / 12	8%
Total	17 / 21	20 / 21	14%

*Upstaging by TNM criteria.

The 21 SI-NENs included 3 patients with localized disease, 6 with nodal metastasis according to H&E assessment, and 12 with distant metastases (one was lymph node negative). PCR upstaged 2 of the 3 node negative patients to node positive, and the patient with node negative but metastatic disease was also node positive on PCR. Thus 3 of 21 (14%) patients were upstaged to node positive disease, with 2 patients upstaged in TNM staging.