Table 2.
Associations between ESRD and cancer risk
| |
N |
ESRD |
OR (95%CI) |
P value |
|
|---|---|---|---|---|---|
| N | % | ||||
|
Controls |
99,615 |
357 |
0.36 |
ref |
-- |
|
Overall cancer |
1,029,732 |
3582 |
0.35 |
1.02 (0.91, 1.14) |
0.8 |
|
Specific cancer site: |
|
|
|
|
|
| Tongue |
4,007 |
18 |
0.45 |
1.32 (0.82, 2.13) |
0.3 |
| Gum and other mouth |
3,407 |
<11 |
<0.4 |
0.95 (0.50, 1.78) |
0.9 |
| Esophagus |
10,261 |
39 |
0.38 |
1.02 (0.73, 1.43) |
0.9 |
| Stomach |
20,106 |
118 |
0.59 |
1.45 (1.16, 1.81) |
0.001* |
| Small intestine |
3,502 |
24 |
0.69 |
1.92 (1.27, 2.92) |
0.002 |
| Colon |
104,002 |
390 |
0.37 |
1.17 (1.00, 1.36) |
0.05 |
| Rectum |
33,086 |
91 |
0.28 |
0.82 (0.65, 1.04) |
0.11 |
| Liver |
9,034 |
63 |
0.70 |
1.53 (1.16, 2.01) |
0.003 |
| Gallbladder |
3,430 |
15 |
0.44 |
1.32 (0.78, 2.22) |
0.3 |
| Other biliary |
4,389 |
27 |
0.62 |
1.78 (1.20, 2.65) |
0.004 |
| Pancreas |
29,765 |
122 |
0.41 |
1.21 (0.98, 1.50) |
0.07 |
| Larynx |
7,431 |
33 |
0.44 |
1.15 (0.80, 1.66) |
0.4 |
| Lung |
161,687 |
661 |
0.41 |
1.17 (1.02, 1.34) |
0.02 |
| Soft tissue (including heart) |
4,202 |
<11 |
<0.4 |
0.56 (0.28, 1.12) |
0.1 |
| Melanoma of skin |
24,626 |
75 |
0.30 |
1.07 (0.82, 1.41) |
0.6 |
| Other non-epithelial skin |
3,585 |
17 |
0.47 |
1.58 (0.96, 2.59) |
0.07 |
| Breast |
122,315 |
339 |
0.28 |
1.11 (0.90, 1.38) |
0.3 |
| Cervix |
3,686 |
28 |
0.76 |
2.12 (1.39, 3.23) |
<0.001* |
| Uterine corpus |
24,507 |
66 |
0.27 |
1.05 (0.77, 1.43) |
0.8 |
| Ovary |
14,683 |
40 |
0.27 |
1.07 (0.75, 1.54) |
0.7 |
| Prostate |
193,632 |
336 |
0.17 |
0.42 (0.35, 0.50) |
<0.001* |
| Bladder |
55,559 |
218 |
0.39 |
1.20 (1.00, 1.44) |
0.05 |
| Kidney and renal pelvis |
22,999 |
185 |
0.80 |
2.31 (1.92, 2.78) |
<0.001* |
| Kidney |
20,684 |
177 |
0.86 |
2.42 (2.01, 2.92) |
<0.001* |
| Renal pelvis |
2,315 |
<11 |
<0.4 |
1.13 (0.56, 2.28) |
0.7 |
| Thyroid |
5,520 |
25 |
0.45 |
1.29 (0.85, 1.93) |
0.2 |
| Non-Hodgkin lymphoma |
50,513 |
120 |
0.24 |
0.77 (0.62, 0.96) |
0.02 |
| Multiple myeloma |
13,949 |
92 |
0.66 |
1.77 (1.40, 2.24) |
<0.001* |
| Acute myeloid leukemia |
7,571 |
25 |
0.33 |
1.02 (0.67, 1.53) |
0.9 |
| Chronic myeloid leukemia | 3,271 | 18 | 0.55 | 1.74 (1.08, 2.80) | 0.02 |
Abbreviations: ESRD end-stage renal disease, OR odds ratio, CI confidence interval.
Odds ratios are adjusted for age, race, sex and selection year. Cancers with less than 3000 cases are not shown.
* P-value is significant at Bonferroni p-value threshold of 0.002.