Table 2. List of All Genes Significantly Up-Regulated (P<10−5) by K and D ODNs.
| Gene symbol | K ODN |
D ODN |
||||||
|---|---|---|---|---|---|---|---|---|
| 1 h | 3 h | 9 h | 27 h | 1 h | 3 h | 9 h | 27 h | |
| ACSL1 | 0.9 | 2.3 | 6.8 | 2.7 | 1.3 | 0.9 | 1.6 | 3.5 |
| ADAR | 1.1 | 1.2 | 2.4 | 2.3 | 1.3 | 1.5 | 2.5 | 3.8 |
| AKAP2 | 1.3 | 1.3 | 2.1 | 1.3 | 1.7 | 1.8 | 2.3 | 2.5 |
| AKT1S1 | 1.0 | 1.3 | 4.0 | 2.6 | 1.8 | 2.6 | 2.1 | 2.4 |
| ALG2 | 1.3 | 1.9 | 3.2 | 2.1 | 1.7 | 1.9 | 2.3 | 3.4 |
| ARHGEF3 | 1.7 | 2.8 | 4.3 | 3.3 | 1.3 | 2.3 | 3.1 | 5.4 |
| AZI2 | 1.1 | 1.5 | 2.7 | 1.5 | 1.0 | 1.2 | 1.6 | 3.3 |
| B2M | 1.0 | 1.4 | 3.3 | 2.9 | 1.2 | 1.1 | 1.6 | 3.0 |
| B3GNT2 | 1.1 | 3.6 | 6.0 | 2.6 | 1.2 | 1.7 | 2.7 | 5.0 |
| CBWD5 | 1.1 | 1.3 | 2.7 | 1.8 | 1.3 | 1.3 | 1.9 | 3.3 |
| CHMP5 | 1.3 | 1.7 | 5.6 | 4.4 | 1.3 | 1.6 | 3.2 | 6.9 |
| CYLD | 1.1 | 1.9 | 3.2 | 2.2 | 1.0 | 1.3 | 1.6 | 3.2 |
| DCK | 1.3 | 1.1 | 2.4 | 1.4 | 1.2 | 1.3 | 1.5 | 3.3 |
| DDX58 | 1.1 | 3.1 | 20.7 | 6.8 | 1.0 | 2.2 | 3.9 | 11.2 |
| DDX60 | 0.9 | 0.9 | 7.0 | 7.6 | 0.8 | 0.8 | 2.6 | 11.8 |
| DHX58 | 0.8 | 2.5 | 5.9 | 2.8 | 0.9 | 0.9 | 2.3 | 6.0 |
| DTX3L | 1.2 | 1.8 | 3.2 | 2.6 | 1.2 | 1.8 | 2.1 | 2.9 |
| DYNLT1 | 0.9 | 1.4 | 3.9 | 1.8 | 1.0 | 0.8 | 1.5 | 3.3 |
| EIF2AK2 | 1.4 | 2.0 | 4.3 | 4.2 | 0.9 | 1.0 | 2.0 | 3.2 |
| EPSTI1 | 1.0 | 2.2 | 35.3 | 34.3 | 0.8 | 1.3 | 8.3 | 37.8 |
| FYTTD1 | 1.1 | 1.3 | 2.8 | 1.7 | 1.1 | 1.2 | 1.5 | 2.5 |
| GCH1 | 1.1 | 1.6 | 4.6 | 1.9 | 1.2 | 1.6 | 1.8 | 3.2 |
| GMPR | 1.2 | 1.8 | 6.8 | 5.1 | 1.2 | 1.5 | 3.4 | 7.2 |
| GNB4 | 0.9 | 1.2 | 2.4 | 1.5 | 1.4 | 1.1 | 1.9 | 3.6 |
| H3F3A/B | 1.1 | 3.0 | 8.1 | 4.9 | 1.1 | 1.4 | 2.6 | 6.9 |
| HERC5 | 1.1 | 2.6 | 16.9 | 10.1 | 0.9 | 1.1 | 3.4 | 14.3 |
| HLA-A | 0.9 | 1.4 | 3.2 | 3.5 | 1.3 | 1.7 | 1.7 | 4.4 |
| HLA-C | 0.8 | 1.4 | 3.5 | 3.5 | 1.4 | 1.8 | 2.1 | 6.1 |
| HLA-G | 0.9 | 1.5 | 3.7 | 3.4 | 1.1 | 1.2 | 1.8 | 3.7 |
| IFI6 | 0.9 | 1.2 | 10.2 | 10.2 | 0.7 | 0.8 | 1.8 | 10.1 |
| IFI44 | 0.9 | 2.5 | 15.5 | 37.7 | 0.9 | 0.9 | 8.2 | 36.1 |
| IFI44L | 0.9 | 2.4 | 7.4 | 11.5 | 0.8 | 1.2 | 4.2 | 8.2 |
| IFIH1 | 1.1 | 5.2 | 30.8 | 12.2 | 0.9 | 1.6 | 4.4 | 17.4 |
| IFIT1 | 1.2 | 13.7 | 23.4 | 9.5 | 0.1 | 5.7 | 9.8 | 19.9 |
| IFIT2 | 1.2 | 39.6 | 42.0 | 23.6 | 0.9 | 6.6 | 5.2 | 16.2 |
| IFIT3 | 0.8 | 3.5 | 5.1 | 6.3 | 0.9 | 2.7 | 5.3 | 7.6 |
| IFIT5 | 0.8 | 5.6 | 8.2 | 3.9 | 0.9 | 1.4 | 2.5 | 7.2 |
| IFITM2 | 1.0 | 1.9 | 8.9 | 11.4 | 1.1 | 1.7 | 5.0 | 21.3 |
| IRF7 | 1.2 | 2.2 | 4.6 | 5.4 | 1.4 | 1.6 | 3.3 | 4.5 |
| ISG15 | 1.2 | 6.0 | 24.8 | 35.8 | 1.1 | 2.2 | 9.9 | 30.2 |
| ISG20 | 0.9 | 2.3 | 15.6 | 12.3 | 0.9 | 1.4 | 4.1 | 14.9 |
| KIAA0040 | 0.9 | 1.5 | 3.3 | 1.6 | 1.0 | 1.1 | 2.1 | 3.5 |
| LAP3 | 1.0 | 1.5 | 4.8 | 3.0 | 0.9 | 1.2 | 2.4 | 5.6 |
| MASTL | 1.0 | 2.5 | 4.1 | 1.9 | 1.3 | 1.0 | 2.5 | 3.3 |
| MFN1 | 1.0 | 1.3 | 2.4 | 1.7 | 1.0 | 0.9 | 1.3 | 2.3 |
| MT1F | 1.4 | 1.5 | 2.4 | 2.1 | 1.6 | 1.5 | 1.3 | 2.0 |
| MX1 | 1.1 | 4.9 | 27.1 | 31.6 | 0.9 | 1.4 | 11.7 | 29.3 |
| NCOA7 | 1.4 | 2.3 | 5.0 | 2.4 | 1.1 | 1.4 | 2.1 | 4.4 |
| NFKB1 | 0.9 | 2.4 | 4.6 | 2.3 | 1.0 | 1.2 | 1.6 | 3.1 |
| NFYB | 1.4 | 1.3 | 2.8 | 1.4 | 1.1 | 1.5 | 1.6 | 3.3 |
| NLRC5 | 1.0 | 1.0 | 2.6 | 1.9 | 0.8 | 0.9 | 2.1 | 2.7 |
| NMI | 1.4 | 1.3 | 3.5 | 2.6 | 1.2 | 1.5 | 2.2 | 4.4 |
| NT5C3 | 1.1 | 3.2 | 34.1 | 20.0 | 0.6 | 1.0 | 2.7 | 15.6 |
| NUB1 | 0.9 | 1.3 | 2.1 | 1.9 | 1.0 | 1.1 | 1.6 | 2.2 |
| OAS2 | 1.0 | 6.4 | 30.9 | 46.2 | 1.3 | 2.4 | 18.9 | 56.8 |
| OAS3 | 0.9 | 1.3 | 7.7 | 5.7 | 0.8 | 0.8 | 2.6 | 8.2 |
| PARP9 | 0.8 | 3.0 | 13.5 | 6.1 | 0.8 | 1.4 | 4.3 | 10.9 |
| PARP12 | 0.9 | 2.6 | 7.2 | 4.7 | 0.7 | 0.9 | 1.4 | 3.3 |
| PARP14 | 1.2 | 3.6 | 13.9 | 16.3 | 1.3 | 2.0 | 8.7 | 21.0 |
| PI4K2B | 1.0 | 2.1 | 4.5 | 2.3 | 0.8 | 1.1 | 1.4 | 2.9 |
| PNPT1 | 1.0 | 1.8 | 7.8 | 3.8 | 1.0 | 1.2 | 2.3 | 6.3 |
| PSMA2 | 1.2 | 1.1 | 2.6 | 2.0 | 1.3 | 1.5 | 1.7 | 3.3 |
| PSMA4 | 1.0 | 0.9 | 3.2 | 1.7 | 1.1 | 1.3 | 1.6 | 2.9 |
| RABGAP1L | 1.1 | 1.4 | 4.7 | 3.3 | 1.1 | 1.2 | 2.4 | 6.5 |
| RBBP6 | 0.8 | 1.4 | 2.4 | 1.2 | 0.9 | 1.0 | 1.2 | 2.0 |
| RGL1 | 1.4 | 4.0 | 8.9 | 5.8 | 1.2 | 2.1 | 2.8 | 5.8 |
| RHOH | 1.2 | 1.6 | 2.1 | 1.0 | 1.2 | 1.8 | 2.0 | 2.7 |
| RNF213 | 1.0 | 1.6 | 7.8 | 5.2 | 0.9 | 1.1 | 2.8 | 7.4 |
| SAMD9 | 0.9 | 5.7 | 16.5 | 6.6 | 1.0 | 1.2 | 2.6 | 8.9 |
| SAMD9L | 1.0 | 11.1 | 33.5 | 17.2 | 0.5 | 1.2 | 3.8 | 15.9 |
| SAT1 | 1.1 | 1.7 | 6.2 | 3.5 | 1.0 | 1.3 | 1.8 | 5.2 |
| SLAMF7 | 1.1 | 2.8 | 5.0 | 4.4 | 1.2 | 1.8 | 2.3 | 3.3 |
| SP100 | 1.0 | 2.0 | 5.6 | 3.0 | 1.1 | 1.4 | 2.4 | 4.8 |
| SP110 | 1.5 | 2.9 | 7.0 | 7.4 | 1.4 | 2.4 | 5.9 | 10.0 |
| SPATS2L | 1.1 | 0.9 | 3.2 | 2.3 | 0.9 | 0.9 | 2.0 | 5.7 |
| STAP1 | 1.2 | 2.1 | 5.6 | 4.4 | 1.3 | 1.4 | 3.1 | 5.5 |
| STAT1 | 1.0 | 6.4 | 24.1 | 14.9 | 0.9 | 1.6 | 7.2 | 22.5 |
| STX11 | 1.1 | 1.6 | 2.7 | 1.8 | 1.3 | 1.4 | 1.7 | 2.0 |
| TAP1 | 0.8 | 2.0 | 4.8 | 3.5 | 1.2 | 0.8 | 2.4 | 4.3 |
| TDRD7 | 1.2 | 2.2 | 8.4 | 4.5 | 1.0 | 1.3 | 2.7 | 9.0 |
| TMCC3 | 1.2 | 1.3 | 4.2 | 4.8 | 0.7 | 0.7 | 1.8 | 4.8 |
| TNFSF10 | 1.4 | 5.6 | 7.3 | 9.7 | 1.0 | 3.8 | 5.1 | 11.8 |
| TNK2 | 1.0 | 1.4 | 2.5 | 2.2 | 1.2 | 1.4 | 1.9 | 2.6 |
| TRAFD1 | 1.1 | 1.6 | 3.2 | 2.1 | 1.3 | 1.4 | 2.2 | 3.0 |
| TRIM21 | 1.3 | 3.5 | 4.6 | 3.8 | 1.3 | 2.2 | 3.5 | 5.2 |
| TRIM22 | 0.9 | 1.2 | 6.6 | 5.4 | 0.9 | 1.3 | 2.9 | 11.4 |
| UBE2L6 | 1.0 | 2.6 | 17.6 | 13.5 | 0.9 | 1.3 | 4.9 | 28.4 |
| UPK3BL | 1.0 | 1.2 | 2.5 | 2.2 | 1.2 | 1.1 | 1.6 | 2.8 |
| USP25 | 1.1 | 1.1 | 2.9 | 2.1 | 1.2 | 1.2 | 1.8 | 2.9 |
| XRN1 | 1.2 | 1.4 | 4.0 | 2.0 | 1.1 | 1.0 | 1.9 | 4.0 |
| ZNF385B | 0.8 | 1.2 | 2.3 | 1.3 | 1.7 | 2.5 | 2.9 | 1.6 |
| ZNFX1 | 1.1 | 2.3 | 3.5 | 2.5 | 1.1 | 1.5 | 2.3 | 2.7 |
CAL-1 cells were stimulated as described in Fig. 2. All genes up-regulated significantly by K and D ODNs (n=92) at any time-point are shown. Shown in bold are those genes that contribute to antiviral immunity (n=23; GO analysis). The level of gene induction is expressed as the fold increase compared with untreated cells.