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. 2012 Sep 13;8(9):e1002664. doi: 10.1371/journal.pcbi.1002664

Figure 8. Classes of Nav-CLS-induced activities.

Figure 8

(A) Nav-CLS of Gaussian distributions with mean±SD(LS) = [0.5±0.2, 1±0.4, 2.5±1.0, 5±5, 10±5, 20±5, 27±5, 30±5, 20±10]mV. (B)–(I) various activities of a node are demonstrated for increased injury (i.e. > mean(LS)): quiescence (B), burst (C,D), tonic firing (E,F,G), burst (H) and quiescence (I). Insets in (B) and (I) show the effect of injecting a 12 µA/cm2 stimulating current. (J) Doubling the SD(LS) in G from 5 to 10 mV slightly increases the tonic firing rate. (K) Instantaneous firing rate (inverse of the interval between two spikes) for tonic or within-burst spikes, versus mean(LS), corresponding to firing patterns C–H (see color coding). (L) Spike (tonic or intraburst) voltage excursions begin to decrease for mean(LS) >10 mV.