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. 2012 Sep 13;7(9):e44718. doi: 10.1371/journal.pone.0044718

Table 5. Linkage disequilibrium between KIR2DS4 gene variants and KIR2DS5 gene in patients and controls.

Group Haplotypes 2DS4full/2DS5 2DS4del/2DS5 —/DS25 2DS4full/— 2DS4del/— —/—
Controls HFs 0.000 0.006 0.155 0.152 0.558 0.129
r −0.157 −0.282 0.512 0.069 0.123 −0.224
R2 = 0.436 DKL = 0.306 ?2 = 300 df = 2 p<0.00001
Patients with AGR HFs 0.000 0.041 0.048 0.214 0.636 0.061
r −0.138 −0.079 0.39 0.043 0.025 −0.122
R2 = 0.194 DKL = 0.102 ?2 = 17.49 df = 2 p = 0.00016
Patients without AGR HFs 0.005 0.000 0.136 0.131 0.586 0.142
r −0.138 −0.287 0.489 0.042 0.116 −0.198
R2 = 0.395 DKL = 0.278 ?2 = 77.06 df = 2 p<0.00001

Abbreviations: AGR, acute graft rejection; HFs, haplotype frequencies; DKL, Kullback-Leibler divergence from linkage equilibrium; KIR, killer immunoglobulin-like receptor; KIR2DS4fl, KIR2DS4 full length gene; KIR2DS4del, KIR2DS4 22-base pair deletion variant of the KIR2DS4 gene; R2, global squared correlation coefficient for two loci; r, correlation coefficient for alleles frequencies. Likelihood ratio statistics (LRS): {Pts with AGR} vs {Controls+Pts without AGR}; LRS = 11.01; df = 5; p = 0.0513.