Table 2. Biologic parameters for modeling of SIV-specific CD8⁺ T lymphocyte compartment.

Parameter	Definition	Value
IniNR	Initial number of naïve SIV-specific CTLs in a macaque	8.75×104 [44], [49] *
α	Factor for naïve SIV-specific CTL activation relative to virus production	5×10−9/cell/day [29]
δNR	Naïve (resting) CTL death rate	10−3/day [45], [46]
βCD8	Production rate of naïve SIV-specific CTLs	87.5 cells/day**
DCD8	Number of CTL divisions after antigenic stimulation	8 [36], [37]
Revert	Reversion rate of activated CTLs returning to resting	5×10−2 [36], [51]
δMR	Memory resting CTL death rate	3×10−2/day [52], [53], [54]
Memory Factor	Ratio of memory versus naïve CTL activation rates	7 [46], [47]
CCnaive	Mitosis time for naïve CTLs	12 hours [55]
CCmemory	Mitosis time for memory CTLs	6 hours [55]
NCTLd	Doublings for a naïve CTL to become an effector CTL	4 doublings [55]
MCTLd	Doublings for a resting memory CTL to become an effector CTL	1 doubling [55]

The biological constants utilized for modeling of SIV-specific CTLs are listed.

^*Based on Sopper et al describing a total body number of 3.5×10⁹ CD8⁺ T lymphocytes and Blattman et al demonstrating the frequency of epitope precursors to be 5×10⁻⁶, and assuming a persisting CTL response to 5 epitopes.

^**Derived constant calculated from biologically observed steady state value for total body CTLs, frequency of epitope-specific CTLs and loss rate of epitope-specific CTLs (see Supplemental Methods).