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. 2012 Sep 13;7(9):e44293. doi: 10.1371/journal.pone.0044293

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© 2012 Li et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Here , and are the recruitment rate of repair protein, the joining rate of fragments and the release rate of repair protein residue, respectively. A short DNA fragment of length has only one binding site (1) and a long DNA fragment of length has two binding sites (2). Joining with a short DNA fragment results in the formation of a protein residue that prevents the recruitment of new protein on both ends (3) or on only one end (4). The residue resulting from the joining of two long fragments is ignorable because it does not affect the recruitment of new proteins (5). Non-ignorable protein residue must be released to make binding site(s) accessible by new proteins(6–7).

Inline graphic — Here , and are the recruitment rate of repair protein, the joining rate of fragments and the release rate of repair protein residue, respectively. A short DNA fragment of length has only one binding site (1) and a long DNA fragment of length has two binding sites (2). Joining with a short DNA fragment results in the formation of a protein residue that prevents the recruitment of new protein on both ends (3) or on only one end (4). The residue resulting from the joining of two long fragments is ignorable because it does not affect the recruitment of new proteins (5). Non-ignorable protein residue must be released to make binding site(s) accessible by new proteins(6–7).