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. 2012 Sep 13;8(9):e1002910. doi: 10.1371/journal.ppat.1002910

Figure 8. Model for secretion of IcmS/IcmW-dependent effectors by DotL.

Figure 8

The transmembrane-spanning L. pneumophila T4SS complex is represented by a purple cylinder, components of the T4CP subcomplex (DotL, DotM, IcmS, and IcmW) are labeled and the inner and outer membranes are indicated as IM and OM, respectively. (A) Export of IcmSW-dependent substrates in a wild type strain. (B) Rejection of IcmSW-dependent substrates in a dotL mutant strain that lacks the IcmSW-dependent binding domain (dotL −S/W). (C) Jamming of IcmSW-dependent substrates in a ΔicmS mutant, leads to DotL degradation by ClpAP.