Table 1. List of the 15 trancripts selected for validation.
Name | Accession | Function | miR-210(M) | miR-147a(M) | miR-147b(M) | miR-210(seed) | miR-147a(seed) | miR-147b(seed) |
ALDH5A1 | NM_001080.3 | dehydrogenase (M) | −0.67 | 0.08 | −0.45 | 2–8 | 1–8 | 2–7 |
BDKRB2 | NM_000623.2 | Bradykinin Receptor | −0.58 | −0.31 | −0.35 | 1–9 | (6) | 2–9 |
COL4A2 | NM_001846.2 | Collagene | −1.51 | −0.05 | −0.96 | 2–7 | 1–9 | 1–9 |
E2F3* | NM_001949.2 | Transcription factor | 0.07 | −0.25 | 0.05 | 1–8 | (4) | 2–7 |
EHD2 | NM_014601.2 | Actin biding protein | −0.87 | −0.86 | −0.41 | 2–10 | 1–8 | 1–7 |
FOXN3 | NM_005197.3 | Transcription factor | −0.55 | −0.02 | −0.32 | 2–14 | (19) | 1–7 |
IER5 | NM_016545.4 | −0.33 | −0.37 | −0.64 | 1–7 | (0) | 2–15 | |
IGFBP3 | NM_000598.4 | Insulin binding protein | −1.32 | −0.34 | −0.95 | 1–11 | 1–9 | 2–7 |
INPP5A | NM_005539.3 | Phosphatase | −0.75 | −0.60 | −0.28 | 1–8 | 1–9; 1–7 | 2–7 |
MAPK6 | NM_002748.3 | Ser/Thr kinase | 0.35 | −0.65 | 0.24 | (0) | 2–7 | (0) |
MCM3 | NM_002388.3 | pre-replication complex | 0.02 | −0.92 | −0.13 | (0) | 2–8 | (0) |
NDUFA4* | NM_002489.2 | dehydrogenase (M) | −1.75 | −2.17 | −2.15 | 2–11 | (0) | 2–9 |
PSMA4 | NM_002789.4 | proteasome | −0.25 | −1.05 | 0.02 | (0) | 1–10 | (0) |
SDHD* | NM_003002.1 | dehydrogenase (M) | −0.45 | 0.00 | −0.31 | 2–7 | (0) | 2–13 |
SH3BGRL | NM_003022.1 | unknown | −0.91 | 0.27 | −0.34 | 2–12 | (0) | 2–7 |
The list of 15 transcripts predicted to be targeted at least by one of the 3 miRNAs using the bioinformatics tool miRonTop are listed. M correspond to the Logarithm (base 2) of the ratio between each miRNA versus miR Neg. Bold values indicated a ratio above the threshold selected. The different types of base-pairing (seed) are listed; numbers inside brackets indicate the number of potential miRNA sites. * corresponds to previously validated targets from [26], [50].