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The structures of novel 1,2,3,4-tetrahydroisoquinoline alkaloids. Ecteinascidin-770 (ET-770, the compound 1a), Ecteinascidin-743 (ET-743, the compound 1b), renieramycin M (the compound 2a), renieramycin E (the compound 2b), and a 2’-N-4”-pyridinecarbonyl derivative of ET-770 (the compound 3) are shown. The present study focused on cytotoxic effects of the compounds 1a, 2a, and 3.
