Figure 4.

The genes downregulated or upregulated in U373MG cells following exposure to the anti-cancer chemical compounds. The genome-wide gene expression profile was studied in U373MG cells exposed for 24 hours to the vehicle (DMSO) or to the chemical compounds 1a, 2a, or 3 individually at the concentration of IC₅₀. The fold changes greater than 3 or smaller than 0.3333, calculated by the expression levels in the compound-treated cells divided by those in the vehicle-treated cells, were considered as substantial upregulation or downregulation. The number of downregulated or upregulated genes is shown.