Table 2.
List of KDM genes described as relevant for PCa. For gene aliases, see Table 1
| GENE | ROLE IN PROSTATE CANCER | REF. |
|---|---|---|
| KDM1A |
Oncogene, AR co-activator, associated with higher relapse risk |
25-28 |
| KDM2A |
Putative tumor suppressor, reduced expression in PCa |
41 |
| KDM3A |
Putative oncogene, overexpressed in PCa, AR co-activator |
30, 33 |
| KDM4A |
Overexpressed in PCa |
33 |
| KDM4B |
Overexpressed in PCa |
33 |
| KDM4C |
Putative oncogene, overexpressed in CRPC, AR co-activator |
30-32 |
| KDM5B |
Overexpressed in metastatic PCa, AR-co-activator |
35 |
| KDM5C |
Putative oncogene, overexpressed in PCa, suppresses TGFB signalling |
36 |
| KDM6B |
Putative oncogene, overexpressed in metastatic PCa |
38 |
| PHF8 | Putative oncogene, overexpressed in PCa, mediates cell invasion | 33 |